AF167: 1-Cys Peroxiredoxin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels which mediate signal transduction in mammalian cells. Prxs can be regulated by changes to phosphorylation, redox and possibly oligomerisation states. Prxs are divided into three classes: typical 2-Cys Prxs; atypical 2-Cys Prxs; and 1-Cys Prxs. All Prxs share the same basic catalytic mechanism, in which an active-site cysteine is oxidised to a sulphenic acid by the peroxide substrate. The recycling of the sulphenic acid back to a thiol is what distinguishes the three enzyme classes [1].

Allergens from this family

Wheat peroxiredoxin was detected as a minor allergen binding IgE predominantly from patients with baker's asthma [2].



  1. Chae HZ, Robison K, Poole LB, Church G, Storz G, Rhee SG:
    Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.
    Proc Natl Acad Sci U S A 1994, 91, 7017-21. [PubMed]
  2. Pahr S, Constantin C, Mari A, Scheiblhofer S, Thalhamer J, Ebner C, Vrtala S, Mittermann I, Valenta R:
    Molecular characterization of wheat allergens specifically recognized by patients suffering from wheat-induced respiratory allergy.
    Clin Exp Allergy 2012, 42, 597-609. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00578 AhpC/TSA family CL0172 Thioredoxin-like
PF10417 C-terminal domain of 1-Cys peroxiredoxin -

Links to Wikipedia


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