AF172: RNA recognition motif

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The RNA recognition motif (RRM, RBD, or RNP domain) is found in a variety of RNA-binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing (SR, U2AF, Sxl), protein components of small nuclear ribonucleoproteins (U1 and U2 snRNPs), and proteins that regulate RNA stability and translation (PABP, La, Hu). The typical RRM consists of four anti-parallel beta-strands and two alpha-helices arranged in a beta-alpha-beta-beta-alpha-beta fold with side chains that stack with RNA bases [1].

Allergens from this family

The fungal allergen Cop c 3 from shaggy mane (Coprinus comatus) belongs to this family.



  1. Clery A, Blatter M, Allain FH:
    RNA recognition motifs: boring? Not quite.
    Curr Opin Struct Biol 2008, 18, 290-8. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CL0221 RRM-like clan

Links to Wikipedia


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