AF181: Hydrophobic surface binding protein A

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

These fungal proteins are typically between 171 and 275 amino acids in length. Although the HsbA amino acid sequence suggests that HsbA may be hydrophilic, it adsorbs to hydrophobic PBSA (polybutylene succinate-co-adipate) surfaces in the presence of NaCl or CaCl2+ and thereby promotes PBSA degradation via the CutL1 polyesterase [1].

Allergens from this family

AFMP1 (Asp f 17) from Aspergillus fumigatus, a cell wall galactomannoprotein, belongs to this family. The allergological significance of this protein is unknown. Patients with aspergillosis develop antibodies against this protein [2].



  1. Ohtaki S, Maeda H, Takahashi T, Yamagata Y, Hasegawa F, Gomi K, Nakajima T, Abe K:
    Novel hydrophobic surface binding protein, HsbA, produced by Aspergillus oryzae.
    Appl Environ Microbiol 2006, 72, 2407-13. [PubMed] [Full Text]
  2. Yuen KY, Chan CM, Chan KM, Woo PC, Che XY, Leung AS, Cao L:
    Characterization of AFMP1: a novel target for serodiagnosis of aspergillosis.
    J Clin Microbiol 2001, 39, 3830-7. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF12296 Hydrophobic surface binding protein A -


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