Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an enzyme of about 37 kDa that catalyzes the sixth step of glycolysis, the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of apoptosis, and ER to Golgi vesicle shuttling .
Tri a 34, the GAPDH from wheat, was identified as a minor allergen for patients with baker's asthma .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00044||Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain||CL0063||FAD/NAD(P)-binding Rossmann fold Superfamily|
|PF02800||Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain||CL0139||Amino acid biosynthesis and glycosomal dehydrogenase|
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