AF184: Glyceraldehyde 3-phosphate dehydrogenase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is an enzyme of about 37 kDa that catalyzes the sixth step of glycolysis, the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate. In addition to this long established metabolic function, GAPDH has recently been implicated in several non-metabolic processes, including transcription activation, initiation of apoptosis, and ER to Golgi vesicle shuttling [1].

Allergens from this family

Tri a 34, the GAPDH from wheat, was identified as a minor allergen for patients with baker's asthma [2].



  1. Tristan C, Shahani N, Sedlak TW, Sawa A:
    The diverse functions of GAPDH: views from different subcellular compartments.
    Cell Signal 2011, 23, 317-23. [PubMed] [Full Text]
  2. Sander I, Rozynek P, Rihs HP, van Kampen V, Chew FT, Lee WS, Kotschy-Lang N, Merget R, Bruning T, Raulf-Heimsoth M:
    Multiple wheat flour allergens and cross-reactive carbohydrate determinants bind IgE in baker's asthma.
    Allergy 2011, 66, 1208-15. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain CL0063 FAD/NAD(P)-binding Rossmann fold Superfamily
PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain CL0139 Amino acid biosynthesis and glycosomal dehydrogenase

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .