AF193: Transaldolase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Transaldolase is an enzyme of the non-oxidative phase of the pentose phosphate pathway. It catalyzes the reversible transfer of dihydroxyacetone from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate, giving rise to erythrose 4-phosphate and fructose 6-phosphate.

Allergens from this family

Transaldolase was identified as cross-reactive mould allergen in Cladosporium cladosporioides (Cla c 14) and Penicillium chrysogenum (Pen ch 35) [1]. These allergens showed cross-reactivity with the human enzyme.



  1. Chou H, Tam MF, Chiang CH, Chou CT, Tai HY, Shen HD:
    Transaldolases are novel and immunoglobulin E cross-reacting fungal allergens.
    Clin Exp Allergy 2011, 41, 739-49. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00923 Transaldolase/Fructose-6-phosphate aldolase CL0036 Common phosphate binding-site TIM barrel superfamily

Links to Wikipedia


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