AF195: Group 7 mite allergen

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Members of this family have been found exclusively in arthropods. Their function is unknown. Structure analysis of the mite allergen Der p 7 revealed an elongated structure with two 4-stranded antiparallel beta-sheets that wrap around a long C-terminal helix. The fold is similar to that of LPS-binding protein (LBP), which interacts with Toll-like receptors after binding LPS and other bacterially derived lipid ligands. However, Der p 7 did not bind LPS but bound with weak affinity to the bacterial lipopeptide polymyxin B [1].

Allergens from this family

Der p 7 and Der f 7 are cross-reactive allergens binding IgE from about half of mite allergic patients [2].



  1. Mueller GA, Edwards LL, Aloor JJ, Fessler MB, Glesner J, Pomes A, Chapman MD, London RE, Pedersen LC:
    The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins.
    J Allergy Clin Immunol 2010, 125, 909-17 e4. [PubMed] [Full Text]
  2. Shen HD, Chua KY, Lin WL, Hsieh KH, Thomas WR:
    Molecular cloning and immunological characterization of the house dust mite allergen Der f 7.
    Clin Exp Allergy 1995, 25, 1000-6. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF16984 Group 7 allergen -


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