AF196: Alt a 1 family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Members of this family are found exclusively in fungi. Their function is unknown. The structure of Alt a 1 from Alternaria alternata was determined. The allergen folds into a unique 11-stranded β-barrel and forms dimers connected by a single disulfide bond [1].

Allergens from this family

Alt a 1 is a major allergen binding IgE from more than 90% of patients allergic to Alternaria [2].



  1. Chruszcz M, Chapman MD, Osinski T, Solberg R, Demas M, Porebski PJ, Majorek KA, Pomes A, Minor W:
    Alternaria alternata allergen Alt a 1: a unique beta-barrel protein dimer found exclusively in fungi.
    J Allergy Clin Immunol 2012, 130, 241-7 e9. [PubMed] [Full Text]
  2. Asturias JA, Ibarrola I, Ferrer A, Andreu C, Lopez-Pascual E, Quiralte J, Florido F, Martinez A:
    Diagnosis of Alternaria alternata sensitization with natural and recombinant Alt a 1 allergens.
    J Allergy Clin Immunol 2005, 115, 1210-7. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF16541 Alternaria alternata allergen 1 -


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