AF197: Fructose bisphosphate aldolase class I

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Fructose-bisphosphate aldolase, often just aldolase, is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase can also produce DHAP from other (3S,4R)-ketose 1-phosphates such as fructose 1-phosphate and sedoheptulose 1,7-bisphosphate. Gluconeogenesis and the Calvin cycle use the reverse reaction. Aldolases are divided into two classes by mechanism [1]. Members of both families fold into a TIM barrel but show little sequence similarity. With few exceptions, only class I proteins have been found in animals, plants, and green algae while only class II proteins have been found in fungi. Both classes have been found widely in other eukaryotes and in bacteria.

Allergens from this family

Aldolases were identified as major fish allergens with limited cross-reactivity [2].



  1. Tittmann K:
    Sweet siblings with different faces: the mechanisms of FBP and F6P aldolase, transaldolase, transketolase and phosphoketolase revisited in light of recent structural data.
    Bioorg Chem 2014, 57, 263-80. [PubMed] [Full Text]
  2. Kuehn A, Hilger C, Lehners-Weber C, Codreanu-Morel F, Morisset M, Metz-Favre C, Pauli G, de Blay F, Revets D, Muller CP, Vogel L, Vieths S, Hentges F:
    Identification of enolases and aldolases as important fish allergens in cod, salmon and tuna: component resolved diagnosis using parvalbumin and the new allergens.
    Clin Exp Allergy 2013, 43, 811-22. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00274 Fructose-bisphosphate aldolase class-I CL0035 Peptidase clan MH/MC/MF

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .