AF198: Ferritin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Ferritin is one of the major non-haem iron storage proteins in animals, plants, and microorganisms [1]. It consists of a mineral core of hydrated ferric oxide, and a multi-subunit protein shell that encloses the former and assures its solubility in an aqueous environment. The main structural domain of ferritin is also found in other ferritin-like proteins such as members of the DNA protection during starvation (DPS) family and bacterioferritins.

Allergens from this family

Der f 30 from the house dust mite Dermatophagoides farinae was identified as IgE binding ferritin by 2-dimensional immunoblotting [2].



  1. Chiancone E, Ceci P, Ilari A, Ribacchi F, Stefanini S:
    Iron and proteins for iron storage and detoxification.
    Biometals 2004, 17, 197-202. [PubMed]
  2. An S, Chen L, Long C, Liu X, Xu X, Lu X, Rong M, Liu Z, Lai R:
    Dermatophagoides farinae allergens diversity identification by proteomics.
    Mol Cell Proteomics 2013, 12, 1818-28. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00210 Ferritin-like domain CL0044 Ferritin-like Superfamily

Links to Wikipedia


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