AF202: Eukaryotic porin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This entry represents both eukaryotic mitochondrial porins and Tom40 proteins [1]. Mitochondrial porins are voltage-dependent anion-selective channels that behave as general diffusion pores for small hydrophilic molecules. They are beta-barrel proteins, composed of between 12 to 16 beta-strands that span the mitochondrial outer membrane. Tom40 is a mitochondrial outer membrane protein and a component of the TOM (translocator of the outer mitochondrial membrane) complex, which is essential for import of protein precursors into mitochondria.

Allergens from this family

Aed a 6, an allergen from the yellow fever mosquito, belongs to this family.



  1. Bay DC, Hafez M, Young MJ, Court DA:
    Phylogenetic and coevolutionary analysis of the beta-barrel protein family comprised of mitochondrial porin (VDAC) and Tom40.
    Biochim Biophys Acta 2012, 1818, 1502-19. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01459 Eukaryotic porin CL0193 Outer membrane beta-barrel protein superfamily

Links to Wikipedia


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