AF207: Zinc finger, C3HC4 type (RING finger)

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions in order to stabilize the fold. Zinc finger proteins are classified into several structural families. These families are defined by the three-dimensional structure as well as by the primary structure of the protein and the identity of the ligands coordinating the zinc ion. The vast majority typically function as interaction modules that bind DNA, RNA, proteins, or small molecules. The RING (Really Interesting New Gene) finger domain is a zinc finger which contains a Cys3HisCys4 motif that binds two zinc ions. Many proteins containing a RING finger play a key role in the ubiquitination pathway [1].

Allergens from this family

Tri a 41, a mitochondrial ubiquitin ligase activator of NFκB, was identified as a minor wheat allergen.



  1. Joazeiro CA, Weissman AM:
    RING finger proteins: mediators of ubiquitin ligase activity.
    Cell 2000, 102, 549-52. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF13920 Zinc finger, C3HC4 type (RING finger) CL0229 Ring-finger/U-box superfamily

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .