AF210: Nematode ASABF-related

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family of disulfide-rich anti-microbial peptides was found in nematodes. The first identified family member was Ascaris suum anti-bacterial factor (ASABF). These proteins are able to kill bacteria and yeast [1, 2].

Allergens from this family

The only non-nematode member of this family identified so far ist the mite allergen Blo t 19 [3].



  1. Zhang H, Yoshida S, Aizawa T, Murakami R, Suzuki M, Koganezawa N, Matsuura A, Miyazawa M, Kawano K, Nitta K, Kato Y:
    In vitro antimicrobial properties of recombinant ASABF, an antimicrobial peptide isolated from the nematode Ascaris suum.
    Antimicrob Agents Chemother 2000, 44, 2701-5. [PubMed]
  2. Kato Y, Aizawa T, Hoshino H, Kawano K, Nitta K, Zhang H:
    abf-1 and abf-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans.
    Biochem J 2002, 361, 221-30. [PubMed]
  3. Thomas WR, Smith WA, Hales BJ, Mills KL, O'Brien RM:
    Characterization and immunobiology of house dust mite allergens.
    Int Arch Allergy Immunol 2002, 129, 1-18. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF16839 Nematode antimicrobial peptide -


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