AF212: GASA/snakin family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains plant proteins whose expression is up-regulated by the plant hormone gibberellin. Most of these proteins have some role in plant hormone crosstalk, development, redox homeostasis and defense. Their sequences contain 12 conserved cysteines which form 6 disulfide bonds [1, 2].

Allergens from this family

Pru p 7 (also named peamaclein) is a highly thermostable allergen from peach, which is capable of eliciting severe allergic reactions [3, 4]. An allergenic member of this family was also identified in orange and named Cit s 7.



  1. Nahirnak V, Almasia NI, Hopp HE, Vazquez-Rovere C:
    Snakin/GASA proteins: involvement in hormone crosstalk and redox homeostasis.
    Plant Signal Behav 2012, 7, 1004-8. [PubMed] [Full Text]
  2. Yeung H, Squire CJ, Yosaatmadja Y, Panjikar S, Lopez G, Molina A, Baker EN, Harris PW, Brimble MA:
    Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.
    Angew Chem Int Ed Engl 2016, (in press)[PubMed] [Full Text]
  3. Tuppo L, Alessandri C, Pomponi D, Picone D, Tamburrini M, Ferrara R, Petriccione M, Mangone I, Palazzo P, Liso M, Giangrieco I, Crescenzo R, Bernardi ML, Zennaro D, Helmer-Citterich M, Mari A, Ciardiello MA:
    Peamaclein--a new peach allergenic protein: similarities, differences and misleading features compared to Pru p 3.
    Clin Exp Allergy 2013, 43, 128-40. [PubMed] [Full Text]
  4. Inomata N, Okazaki F, Moriyama T, Nomura Y, Yamaguchi Y, Honjoh T, Kawamura Y, Narita H, Aihara M:
    Identification of peamaclein as a marker allergen related to systemic reactions in peach allergy.
    Ann Allergy Asthma Immunol 2014, 112, 175-7 e3. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF02704 Gibberellin regulated protein -


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