AF213: RidA/YjgF/L-PSP family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains trimeric proteins with high functional diversity found in all three domains of life [1]. RidA proteins (also named YjgF) have imine/enamine deaminase activity and function in removing toxic metabolic by-products [2]. Rat liver perchloric acid soluble protein (L-PSP) is an endoribunuclease that cleaves single-stranded DNA. L-PSP was shown to inhibit translation by cleaving mRNA [3].

Allergens from this family

The house dust mite allergen Der f 34 is the only known allergenic member of this family [4]. Der f 34 was shown to have imine deaminase activity and bound IgE from more than 60% of mite allergic patients. Furthermore, IgE cross-reactivity with the mold Aspergillus fumigatus was detected.



  1. Niehaus TD, Gerdes S, Hodge-Hanson K, Zhukov A, Cooper AJ, ElBadawi-Sidhu M, Fiehn O, Downs DM, Hanson AD:
    Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family.
    BMC Genomics 2015, 16, 382. [PubMed] [Full Text]
  2. Lambrecht JA, Schmitz GE, Downs DM:
    RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life.
    MBio 2013, 4, e00033-13. [PubMed] [Full Text]
  3. Morishita R, Kawagoshi A, Sawasaki T, Madin K, Ogasawara T, Oka T, Endo Y:
    Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis.
    J Biol Chem 1999, 274, 20688-92. [PubMed]
  4. ElRamlawy KG, Fujimura T, Baba K, Kim JW, Kawamoto C, Isobe T, Abe T, Hodge-Hanson K, Downs DM, Refaat IH, Al-Azhary DB, Aki T, Asaoku Y, Hayashi T, Katsutani T, Tsuboi S, Ono K, Kawamoto S:
    Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases.
    J Biol Chem 2016, (in press)[PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01042 Endoribonuclease L-PSP CL0534 YjgF-like superfamily


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