• BRIGHT BRAINS ATTRACT BRIGHT BRAINS, Matthew principle BBABB

functional PET (fPET)



Principal Investigator: Andreas Hahn, Ass.Prof.

The assessment of task-specific changes in glucose metabolism previously required repeated scans and radioligand applications, with drawbacks of increased radiation burden and variance due to differences in task performance, motivation and habituation.

Functional PET (fPET) imaging with the radiotracer [18F]FDG refers to a novel method to study dynamic changes in glucose metabolism within a single scanning session. The constant infusion protocol provides free radiotracer throughout the scan, which is then available to bind according to the actual metabolism as induced by the experimental task. The term fPET furthermore underlines the similarity to fMRI with respect to repeated task performance in a block design and the analysis with the general linear model to separate task effects from baseline metabolism.

Together with hybrid PET/MR imaging systems, this technique offers new possibilities to study multiple domains of human brain function during task performance.