AF100: Myosin heavy chain

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Myosin is a multi-subunit complex made up of two heavy chains and four light chains. It is a fundamental contractile protein found in all eukaryote cell types [1]. Most myosin molecules are composed of a head, neck, and tail domain. The head domain binds the actin filament and uses ATP hydrolysis to generate force and to "walk" along the filament. The neck domain acts as a linker and as a lever arm for transducing force generated by the catalytic motor domain. It also serves as a binding site for myosin light chains, which are members of the (EF hand family). The tail domain forms a coiled coil and mediates interaction with cargo molecules and other myosin subunits. The coiled-coil is composed of the tails from two molecules of myosin and assembles into the thick filament in muscle cells.

Allergens from this family

The group 11 mite allergens are paramyosins. They are highly cross-reactive major allergens [2].



  1. Sellers JR:
    Myosins: a diverse superfamily.
    Biochim Biophys Acta 2000, 1496, 3-22. [PubMed]
  2. Tsai LC, Peng HJ, Lee CS, Chao PL, Tang RB, Tsai JJ, Shen HD, Hung MW, Han SH:
    Molecular cloning and characterization of full-length cDNAs encoding a novel high-molecular-weight Dermatophagoides pteronyssinus mite allergen, Der p 11.
    Allergy 2005, 60, 927-37. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01576 Myosin tail -

Links to Wikipedia


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