AF119: Triabin family
This family contains saliva proteins from haematophagous insects that counteract vertebrate host haemostasis events such as coagulation, vasoconstriction and platelet aggregation. The members of this family belong to MEROPS proteinase inhibitor family I59. They are structurally related to lipocalins (AllFam:AF015) and are members of the calycin superfamily .
Allergens from this family
The major salivary allergen of California kissing bug (Triatoma protracta), Tria p 1 (procalin), and the major allergen Bla g 4 from German cockroach belong to this family [2, 3].
Molecular cloning and sequencing of salivary gland-specific cDNAs of the blood-sucking bug Triatoma brasiliensis (Hemiptera: Reduviidae).
Insect Mol Biol 2002, 11, 585-93. [PubMed]
Identification, cloning, and recombinant expression of procalin, a major triatomine allergen.
J Immunol 2001, 167, 2694-9. [PubMed]
Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
J Biol Chem 2009, 284, 3148-57. [PubMed] [Full Text]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
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