AF119: Triabin family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains saliva proteins from haematophagous insects that counteract vertebrate host haemostasis events such as coagulation, vasoconstriction and platelet aggregation. The members of this family belong to MEROPS proteinase inhibitor family I59. They are structurally related to lipocalins (AllFam:AF015) and are members of the calycin superfamily [1].

Allergens from this family

The major salivary allergen of California kissing bug (Triatoma protracta), Tria p 1 (procalin), and the major allergen Bla g 4 from German cockroach belong to this family [2, 3].



  1. Sant'Anna MR, Araujo JG, Pereira MH, Pesquero JL, Diotaiuti L, Lehane SM, Lehane MJ:
    Molecular cloning and sequencing of salivary gland-specific cDNAs of the blood-sucking bug Triatoma brasiliensis (Hemiptera: Reduviidae).
    Insect Mol Biol 2002, 11, 585-93. [PubMed]
  2. Paddock CD, McKerrow JH, Hansell E, Foreman KW, Hsieh I, Marshall N:
    Identification, cloning, and recombinant expression of procalin, a major triatomine allergen.
    J Immunol 2001, 167, 2694-9. [PubMed]
  3. Tan YW, Chan SL, Ong TC, Yit le Y, Tiong YS, Chew FT, Sivaraman J, Mok YK:
    Structures of two major allergens, Bla g 4 and Per a 4, from cockroaches and their IgE binding epitopes.
    J Biol Chem 2009, 284, 3148-57. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF03973 Triabin CL0116 Calycin superfamily


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