AF131: Redoxin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The family of redoxins includes several groups of redox enzymes related to thioredoxins (AllFam:AF023), (Pfam:PF00085): peroxiredoxins, thioredoxins and glutaredoxins. Peroxiredoxins constitute a family of thiol peroxidases that reduce hydrogen peroxide, peroxinitrite, and hydroperoxides using a strictly conserved cysteine. Chloroplast thioredoxin systems in plants regulate the enzymes involved in photosynthetic carbon assimilation. It is thought that redoxins have a large role in anti-oxidant defence.

Allergens from this family

Peroxisomal membrane proteins from several fungi were identified as major allergens [1, 2, 3].



  1. Hemmann S, Blaser K, Crameri R:
    Allergens of Aspergillus fumigatus and Candida boidinii share IgE-binding epitopes.
    Am J Respir Crit Care Med 1997, 156, 1956-62. [PubMed] [Full Text]
  2. Yasueda H, Hashida-Okado T, Saito A, Uchida K, Kuroda M, Onishi Y, Takahashi K, Yamaguchi H, Takesako K, Akiyama K:
    Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur.
    Biochem Biophys Res Commun 1998, 248, 240-4. [PubMed] [Full Text]
  3. Shen HD, Wang CW, Chou H, Lin WL, Tam MF, Huang MH, Kuo ML, Wang SR, Han SH:
    Complementary DNA cloning and immunologic characterization of a new Penicillium citrinum allergen (Pen c 3).
    J Allergy Clin Immunol 2000, 105, 827-33. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF08534 Redoxin CL0172 Thioredoxin-like

Links to Wikipedia


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