AF146: Troponin I and T

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The troponin complex regulates Ca2+ induced muscle contraction. It consists of three subunits: Ca2+ binding (troponin C), inhibitory (troponin I), and tropomyosin binding (troponin T). Troponin I and T are evolutionary related while troponin C belongs to the EF hand family (AllFam:AF007) [1].

Allergens from this family

Pol l 7, a crayfish troponin I, was identified as a minor allergen.



  1. Ohtsuki I, Morimoto S:
    Troponin: regulatory function and disorders.
    Biochem Biophys Res Commun 2008, 369, 62-73. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00992 Troponin -

Links to Wikipedia


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