AF153: Tick histamine binding protein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Tick histamine binding proteins are secreted into the tick saliva and sequester histamine at the wound site. Because the tick histamine binding proteins outcompete histamine receptors, they are able to overcome host inflammatory responses. These proteins are structurally related to lipocalins (AllFam:AF015) without any significant sequence similarity [1].

Allergens from this family

The European pigeon tick (Argas reflexus) is a parasite of wild pigeons colonizing urban buildings and houses. Occasionally the ticks can bite humans, inducing anaphylactic reactions in sensitized patients. The major allergen, Arg r 1, belongs to the histamine binding protein family [2].



  1. Mans BJ, Ribeiro JM, Andersen JF:
    Structure, function, and evolution of biogenic amine-binding proteins in soft ticks.
    J Biol Chem 2008, 283, 18721-33. [PubMed] [Full Text]
  2. Hilger C, Bessot JC, Hutt N, Grigioni F, De Blay F, Pauli G, Hentges F:
    IgE-mediated anaphylaxis caused by bites of the pigeon tick Argas reflexus: cloning and expression of the major allergen Arg r 1.
    J Allergy Clin Immunol 2005, 115, 617-22. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF02098 Tick histamine binding protein CL0116 Calycin superfamily


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