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Neuroendocrine pancreatic cancer: mutation mechanism discovered

Result could facilitate targeted treatment of the disease
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(Vienna, 16 July 2020) Although neuroendocrine tumours of the pancreas are rare, the available treatment options are currently limited. Researchers have now managed to identify the mutation mechanism, namely a mutation on the gene that activates the telomerase enzyme TERT, and this will potentially give rise to new treatment options. This discovery could lead to a more targeted treatment for patients who carry this mutation. The study is a joint research initiative of MedUni Vienna, Paracelsus Private Medical University in Salzburg and the Medical University of Innsbruck and was initiated and led by MedUni Vienna. The paper has now been published in the specialist journal "Cancers".

Between 80 and 160 people a year develop a neuroendocrine, that is to say hormone-related, pancreatic tumour. The trend is rising sharply, and it is predominantly older people who are affected. Ten percent of these cancers are hereditary, the rest occur sporadically. It is known that, in the case of hereditary tumours, there is an activating mutation of a specific gene, the Telomerase Reverse Transcriptase (TERT) gene.

Mutation activates telomerase
The reasons behind the mutation of non-hereditary tumours were hitherto unknown. In the recent study, the researchers led by Klaus Holzmann, from MedUni Vienna's Institute of Cancer Research and member of the Comprehensive Cancer Center (CCC) of MedUni Vienna and Vienna General Hospital, have shown that a mutation in the TERT region is also present in around 10% of this patient group. For their analysis they used an extremely sensitive genetic sequencing technique known as pyrosequencing.

Says Holzmann: "The TERT gene promoter mutation results in increased production of the enzyme telomerase. Telomerase enables cells to divide indefinitely, which leads to cancer. If we could manage to inhibit the production of telomerase, we could also stop the uncontrolled growth." Since drugs are already being developed to inhibit the production of telomerase in other forms of cancer, it is hoped that these will also be effective against neuroendocrine pancreatic cancer. The results still need to be validated and refined in further studies but could represent a new targeted therapeutic approach.

What is the function of telomerase?
Telomeres are "caps" on the end of chromosomes, which protect the chromosomes from breaking and hence "fraying", as it were, which would result in cell damage. The telomeres shorten with each cell division. If the telomeres are too short or if the cell loses the ability to produce telomerase, it initiates cell death and dies. The enzyme telomerase can preserve telomeres or at least can restore them to their original length. Many tumours have the ability to reactivate telomerase, which then facilitates unrestricted growth.

Service: Cancers
"Hot Spot TERT Promoter Mutations Are Rare in Sporadic Pancreatic Neuroendocrine Neoplasms and Associated with Telomere Length and Epigenetic Expression Patterns."
Alexandra Posch, Sarah Hofer-Zeni, Eckhard Klieser, Florian Primavesi, Elisabeth Naderlinger, Anita Brandstetter, Martin Filipits, Romana Urbas, Stefan Swiercynski, Tarkan Jäger, Paul Winkelmann, Tobias Kiesslich, Lingeng Lu, Daniel Neureiter, Stefan Stättner, Klaus Holzmann
Cancers 2020, 12, 1625; doi:10.3390/cancers12061625.