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Christian Doppler Laboratory for Multimodal Analytical Imaging of Aging and Senescence of the Skin

SKINMAGINE

The Christian Doppler Laboratory for Multimodal Analytical Imaging of Aging and Senescence of the Skin – “SKINMAGINE”

The Christian Doppler Laboratory SKINMAGINE aims to gain comprehensive insights into cellular aging in the skin by correlating chemistry, metabolism and communication within the tissue at high spatial resolution.

We use an innovative multimodal analytical imaging approach to combine mass spectrometric imaging, automated immunofluorescence- and metabolic activity microscopy, non-invasive imaging technologies and in-tissue reporter systems followed by correlative multimodal analysis. With these technologies we study how individual cells within the human skin and in organotypic skin models change when they become stressed and then senescent in the aging process. We will especially focus on the impact of combined urban pollution and sun exposure on the cellular aging and –senescence process. The lipidome and epilipidome (the chemical modifications of lipids) of cutaneous stress and senescence are a major aim of this CDL, as well as other metabolic adaptations in aging. We will investigate adapations to quality control in senescent cells within the tissue context, especially how the (epi-)transcriptome and translatome change in the senescence process, and we will gain insights on the communication of senescent cells in the tissue context. 

Florian Gruber points at a computer screen

Together with our industry partner CHANEL Parfums Beauté we will translate our findings to investigate how candidate skin care active substances prevent aging promoting stress or limit negative consequences.

The team consists of Florian Grubers workgroup at the MedUni Vienna and the external modules at the BOKU Wien (headed by Markus Schosserer) and the TU Wien (headed by Martina Marchetti-Deschmann)

Presentation of the Skinmagine CD-Laboratory

A comprehensive video presentation of the new CD Laboratory is here available.

Videos

MedUni Vienna

Florian Gruber

Florian Gruber

Laboratory Head of SKINMAGINE

Assoz. Prof. Priv.-Doz. Dr. Florian Gruber

Forschungsabteilung für Biologie und Pathobiologie der Haut
Christian Doppler Labor für Multimodales Analytisches Imaging von
Alterung und Seneszenz der Haut - SKINMAGINE
Medizinische Universität Wien - Universitätsklinik für Dermatologie

Research Division of Biology and Pathobiology of the Skin
Christian Doppler Lab for Skin Multimodal Imaging of
Aging and Senescence - SKINMAGINE
Medical University of Vienna - Deptartment of Dermatology

Medizinische Universität Wien
Anna Spiegel Forschungsgebäude
BT25.2 / Ebene 6 / Labor 5
Lazarettgasse 14
A-1090 Wien

Office: +43-1-40400-73734
Lab:    +43-1-40400-73507
Fax:    +43-1-40400-73584
Mobil: +43-6991-9434501

Michaela Sochorová

Michaela Sochorová

Postdoctoral Researcher
Christopher Kremslehner

Christopher Kremslehner

PhD Student
Ionela-Mariana Nagelreiter

Ionela-Mariana Nagelreiter

Lab manager
Yiwen Yang

Yiwen Yang

Guest Researcher

External Module BOKU

Markus Schosserer

Markus Schosserer

Module Head BOKU

External Module TU Wien

Martina Marchetti-Deschmann

Martina Marchetti-Deschmann

Module Head TU
Samuele Zoratto

Samuele Zoratto

Postdoctoral Researcher

EpiLipidNet - Pan-European Network in Lipidomics and Epilipiomics

EpiLipidNet - Pan-European Network in Lipidomics and Epilipiomics

Comulis – Correlated Multimodal Imaging in Life Sciences

Comulis – Correlated Multimodal Imaging in Life Sciences

Cost Epitran- European Epitranscriptomics Network

Cost Epitran- European Epitranscriptomics Network

ViCEM – Vienna Center for Engineering

ViCEM – Vienna Center for Engineering

 

 

 

 

GÖCH –Gesellschaft Österr. Chemiker AG Kosmetik

GÖCH –Gesellschaft Österr. Chemiker AG Kosmetik

 

 

 

 

ÖGDV

ÖGDV

 

 

 

 

Society for Free Radical Research Europe

Society for Free Radical Research Europe

International Federation of Societies of Cosmetic Chemists

International Federation of Societies of Cosmetic Chemists
Microscope

Funding

The Christian Doppler Laboratory for Multimodal Analytical Imaging of Aging and Senescence of the Skin – “SKINMAGINE” is supported by the Christian Doppler Research Association in collaboration with CHANEL Parfums Beauté.