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Researcher of the MedUni Vienna ...Marko Grahovac, MSc Department of Biomedical Imaging and Image-guided Therapy (Clinical Division of Nuclear Medicine)Position: PHD Student ORCID: 0000-0002-3323-778XT +43 1 40400-55850 marko.grahovac@meduniwien.ac.at Keywords Artificial Intelligence; Data Mining; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted Research group(s) Christian Doppler Laboratory for Applied MetabolomicsHead: Lukas KennerResearch Area: We investigate ways to better characterize tumors using non-invasive imaging techniques. This is important because tumours are constantly changing through mutations. In this way, an individual therapy should be possible and its success should be continuously monitored.Members: Marko Grahovac David Haberl Lukas Kenner Kilian Kluge Marzieh Nejabat Jing Ning Research interests Machine learning, image processing, personalized... https://www.meduniwien.ac.at/web/en/forschung/researcher-profiles/researcher-profiles/detail/?name=Marko_Grahovac&res_id=686&cHash=2e0f3beadf186ff424e4b43910b7ca78
Researcher of the MedUni Vienna ...Marko Grahovac, MSc Department of Biomedical Imaging and Image-guided Therapy (Clinical Division of Nuclear Medicine)Position: PHD Student ORCID: 0000-0002-3323-778XT +43 1 40400-55850 marko.grahovac@meduniwien.ac.at Keywords Artificial Intelligence; Data Mining; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted Research group(s) Christian Doppler Laboratory for Applied MetabolomicsHead: Lukas KennerResearch Area: We investigate ways to better characterize tumors using non-invasive imaging techniques. This is important because tumours are constantly changing through mutations. In this way, an individual therapy should be possible and its success should be continuously monitored.Members: Marko Grahovac David Haberl Lukas Kenner Kilian Kluge Marzieh Nejabat Jing Ning Research interests Machine learning, image processing, personalized... https://www.meduniwien.ac.at/web/en/forschung/researcher-profiles/researcher-profiles/detail/?name=Marko_Grahovac&res_id=686&cHash=0b1c330e57b83efdc2a227304a924850
Researcher of the MedUni Vienna ...Marko Grahovac, MSc Department of Biomedical Imaging and Image-guided Therapy (Clinical Division of Nuclear Medicine)Position: PHD Student ORCID: 0000-0002-3323-778XT +43 1 40400-55850 marko.grahovac@meduniwien.ac.at Keywords Artificial Intelligence; Data Mining; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted Research group(s) Christian Doppler Laboratory for Applied MetabolomicsHead: Lukas KennerResearch Area: We investigate ways to better characterize tumors using non-invasive imaging techniques. This is important because tumours are constantly changing through mutations. In this way, an individual therapy should be possible and its success should be continuously monitored.Members: Marko Grahovac David Haberl Lukas Kenner Kilian Kluge Marzieh Nejabat Jing Ning Research interests Machine learning, image processing, personalized... https://www.meduniwien.ac.at/web/forschung/researcher-profiles/researcher-profiles/detail/?name=Marko_Grahovac&res_id=686&cHash=0b1c330e57b83efdc2a227304a924850
Researcher of the MedUni Vienna ...Marko Grahovac, MSc Department of Biomedical Imaging and Image-guided Therapy (Clinical Division of Nuclear Medicine)Position: PHD Student ORCID: 0000-0002-3323-778XT +43 1 40400-55850 marko.grahovac@meduniwien.ac.at Keywords Artificial Intelligence; Data Mining; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted Research group(s) Christian Doppler Laboratory for Applied MetabolomicsHead: Lukas KennerResearch Area: We investigate ways to better characterize tumors using non-invasive imaging techniques. This is important because tumours are constantly changing through mutations. In this way, an individual therapy should be possible and its success should be continuously monitored.Members: Marko Grahovac David Haberl Lukas Kenner Kilian Kluge Marzieh Nejabat Jing Ning Research interests Machine learning, image processing, personalized... https://www.meduniwien.ac.at/web/1/forschung/researcher-profiles/researcher-profiles/index.php?id=688&res=marko_grahovac
Researcher of the MedUni Vienna ...Marko Grahovac, MSc Department of Biomedical Imaging and Image-guided Therapy (Clinical Division of Nuclear Medicine)Position: PHD Student ORCID: 0000-0002-3323-778XT +43 1 40400-55850 marko.grahovac@meduniwien.ac.at Keywords Artificial Intelligence; Data Mining; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted Research group(s) Christian Doppler Laboratory for Applied MetabolomicsHead: Lukas KennerResearch Area: We investigate ways to better characterize tumors using non-invasive imaging techniques. This is important because tumours are constantly changing through mutations. In this way, an individual therapy should be possible and its success should be continuously monitored.Members: Marko Grahovac David Haberl Lukas Kenner Kilian Kluge Marzieh Nejabat Jing Ning Research interests Machine learning, image processing, personalized... https://www.meduniwien.ac.at/web/index.php?id=688&res=marko_grahovac
Researcher of the MedUni Vienna ...Marko Grahovac, MSc Department of Biomedical Imaging and Image-guided Therapy (Clinical Division of Nuclear Medicine)Position: PHD Student ORCID: 0000-0002-3323-778XT +43 1 40400-55850 marko.grahovac@meduniwien.ac.at Keywords Artificial Intelligence; Data Mining; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted Research group(s) Christian Doppler Laboratory for Applied MetabolomicsHead: Lukas KennerResearch Area: We investigate ways to better characterize tumors using non-invasive imaging techniques. This is important because tumours are constantly changing through mutations. In this way, an individual therapy should be possible and its success should be continuously monitored.Members: Marko Grahovac David Haberl Lukas Kenner Kilian Kluge Marzieh Nejabat Jing Ning Research interests Machine learning, image processing, personalized... https://www.meduniwien.ac.at/web/en/research/researcher-profiles/researcher-profiles/index.php?id=688&res=marko_grahovac
News ... können. Diese Studie wurde gerade in Nature Communications (doi:10.1038/ncomms8736) publiziert und als wichtiges Forschungshighlight von Nature Reviews Urology ausgewählt und kommentiert (doi:10.1038/nrurol.2015.205). Die Studie entstand in der Arbeitsgruppe rund um den Wiener Pathologen Lukas Kenner... https://www.meduniwien.ac.at/web/index.php?id=131&L=3&tx_news_pi1%5Bnews%5D=3034&tx_news_pi1%5Bcontroller%5D=News&tx_news_pi1%5Baction%5D=detail&cHash=20bdd334d3fe65a8c78f4d5bf317cbb3
News ... dieser Situation könnte z.B. eine Chemotherapie wesentlich besser wirken„Ziel ist es nun, Substanzen zu finden, die diese Autophagie blockieren können. Danach könnten die klinische Studien starten“, sagt Lukas Kenner vom Klinischen Institut für Pathologie der MedUni Wien und vom Ludwig-Boltzmann-Institut... https://www.meduniwien.ac.at/web/index.php?id=131&L=3&tx_news_pi1%5Bnews%5D=2176&tx_news_pi1%5Bcontroller%5D=News&tx_news_pi1%5Baction%5D=detail&cHash=4d0964903eda75797f1178d8c796410c
“Achillesferse“ der Tumorzellen des anaplastischen-großzelligen Lymphoms (ALCL) identifiziert ... unterstützt. "Daher könnten wir die TYK2-Signale als die Achillesferse der ALCL betrachten, da bei beiden untersuchten ALCL Arten die Tumorzellen auf dessen Aktivität angewiesen sind, um das essentielle Signal zum Schutz vor Zelltod zu erhalten", erklärt Olaf Merkel, der sich gemeinsam mit Lukas Kenner die Letztautorschaft dieser Publikation teilt. Die Verringerung des Tyk2-Signals in der Zellkultur führte zu einem schnellen Zelltod und bei ALCL Modell Mäusen, bei denen TYK2 genetisch ausgeschaltet war, beobachteten die ForscherInnen, dass die Labortiere länger überlebten.Lukas Kenner von der MedUni Wien und vom... https://www.meduniwien.ac.at/web/ueber-uns/news/detailseite/2018/news-im-september-2018/achillesferse-der-tumorzellen-des-anaplastischen-grosszelligen-lymphoms-alcl-identifiziert/?cHash=b09d4d36736b1ad88c0b67566028c877&tx_news_pi1%5BoverwriteDemand%5D%5Bcategories%5D=2
"Achilles heel" of anaplastic large-cell lymphoma (ALCL) cells identified ... that we investigated relied on its activity to maintain the essential signal to protect against cell death," explains Olaf Merkel, who is co-last author of this publication together with Lukas Kenner. Attenuating the TYK2 signal in the cell culture resulted in rapid cell death and, in ALCL model mice, in which TYK2 was genetically switched off, the researchers observed that the laboratory animals survived for longer.Lukas Kenner from MedUni Vienna and the Ludwig Boltzmann Institute for Cancer Research and co-founder of the  European Research Initiative on Alk-mediated diseases (ERIA... https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/2018/news-im-september-2018/achilles-heel-of-anaplastic-large-cell-lymphoma-alcl-cells-identified/?cHash=b09d4d36736b1ad88c0b67566028c877&tx_news_pi1%5BoverwriteDemand%5D%5Bcategories%5D=2