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Thomas M Hofbauer
Dr.med.univ. Thomas M Hofbauer, PhD

Department of Medicine II (Division of Cardiology)
Position: PHD Student

ORCID: 0000-0001-5324-6336
T +43 1 40400 73520
thomas.hofbauer@meduniwien.ac.at

Keywords

Acute Coronary Syndrome; Neutrophil Activation; Pulmonary Artery

Research group(s)

Research interests

Our group specializes in elucidating the role of Neutrophil Extracellular Traps (NETs), an effector mechanism of neutrophil granulocytes, in the pathogenesis of cardiovascular disease (especially acute and chronic coronary syndromes and pulmonary hypertension). Apart from this more translational work, I am currently focus on patient care in the outpatient clinics for pulmonary (arterial) hypertension of our department.

Techniques, methods & infrastructure

Bench

Flow cytometry, enzyme-linked immunosorbent assay, cell culture-based functional assays, immunohistochemistry and immunofluorescence, quantitative polymerase chain reaction.

Translational aspects

Connection of experimental and laboratory measurements with clinical features and mortality of affected patients.


Selected publications

  1. Ondracek, A.S. et al. (2024) ‘Malondialdehyde-specific natural IgM inhibit NETosis triggered by culprit site–derived extracellular vesicles from myocardial infarction patients’, European Heart Journal, 46(10), pp. 926–939. Available at: https://doi.org/10.1093/eurheartj/ehae584.
  2. Hofbauer, T.M. et al. (2021) ‘Deoxyribonuclease 1 Q222R single nucleotide polymorphism and long-term mortality after acute myocardial infarction’, Basic Research in Cardiology, 116(1). Available at: https://doi.org/10.1007/s00395-021-00864-w.
  3. Hofbauer, T.M. et al. (2020) ‘Neutrophil Extracellular Traps Induce MCP-1 at the Culprit Site in ST-Segment Elevation Myocardial Infarction’, Frontiers in Cell and Developmental Biology, 8. Available at: https://doi.org/10.3389/fcell.2020.564169.
  4. Hofbauer, T.M. et al. (2019) ‘Neutrophil extracellular traps and fibrocytes in ST-segment elevation myocardial infarction’, Basic Research in Cardiology, 114(5). Available at: https://doi.org/10.1007/s00395-019-0740-3.
  5. Mangold, A. et al. (2015) ‘Coronary Neutrophil Extracellular Trap Burden and Deoxyribonuclease Activity in ST-Elevation Acute Coronary Syndrome Are Predictors of ST-Segment Resolution and Infarct Size’, Circulation Research, 116(7), pp. 1182–1192. Available at: https://doi.org/10.1161/circresaha.116.304944.