Department of Neurology
Position: Research Associate (Postdoc)
T +43 1 40400 31270
theresa.koenig@meduniwien.ac.at
Keywords
Dementia; Genetics; Neurodegeneration; Neurodegenerative Diseases; Neuroinflammation
Research interests
My research focuses mainly on genetic factors and immunological processes in neurological diseases, especially the complex interplay between risk genes and the immune system in neurodegenerative and inflammatory diseases such as Alzheimer's disease, Parkinson's disease, and Multiple Sclerosis.
By analyzing cerebrospinal fluid, blood samples, and genetic data obtained from patients, we aim to identify novel biomarkers and answer essential questions about the pathogenesis of these devastating disorders.
A primary goal is to investigate the phenotypic consequences of genetic variations, altered gene-expression and changes in the immune-profile to translate our findings into clinical applications, such as early diagnosis, improved patient stratification and personalized treatment strategies.
Selected publications
- König, T. et al. (2022) ‘C9orf72 repeat length might influence clinical sub-phenotypes in dementia patients’, Neurobiology of Disease, 175, p. 105927. Available at: http://dx.doi.org/10.1016/j.nbd.2022.105927.
- Mir, R. et al. (2018) ‘The Parkinson’s disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human’, Biochemical Journal, 475(11), pp. 1861–1883. Available at: http://dx.doi.org/10.1042/bcj20180248.
- Parvizi, T. et al. (2022) ‘Real-world applicability of glial fibrillary acidic protein and neurofilament light chain in Alzheimer’s disease’, Frontiers in Aging Neuroscience, 14. Available at: http://dx.doi.org/10.3389/fnagi.2022.887498.
- Dorninger, F. et al. (2019) ‘Disturbed neurotransmitter homeostasis in ether lipid deficiency’, Human Molecular Genetics, 28(12), pp. 2046–2061. Available at: http://dx.doi.org/10.1093/hmg/ddz040.
- Meka, D.P. et al. (2019) ‘Radial somatic F‐actin organization affects growth cone dynamics during early neuronal development’, EMBO reports, 20(12). Available at: http://dx.doi.org/10.15252/embr.201947743.