Detail

Keywords

Biocompatible Materials; Cell Culture Techniques; Dental Bonding; Dental Cements; Fibroblasts

Research group(s)

• Competence Center Dental Materials
  Research Area: For the best possible restoration of damaged teeth, dental materials and their manufacture are as important as the skills of the dentist. The Competence Center Dental Materials focuses on the development of preclinical tests and on scientific quality assurance in dentistry.
  Members:
  Alexander Franz
  Andreas Schedle

Research interests

Test protocols for cytotoxicity testing require fine tuning for oral biomaterials to obtain international comparability as the basis for risk assessment. Therefore my main research focus is to develop standardized test protocols for dental materials resembling conditions similar to the oral cavity.

Techniques, methods & infrastructure

Cytotoxicity of a variety of dental materials is tested using cell lines (e.g. L929 mouse fibroblasts, primary human gingival fibroblasts). Different test specimens and environmental conditions are applied. Protocols are in line with ISO 7405.

Selected publications

1. Franz, A. et al., 2018. Analysis of pre-test failures and bond-strengths of seven adhesive systems to bovine dentine: A nine-year novice/beginner operator study. Dental Materials, 34(11), pp.1599-1609. Available at: http://dx.doi.org/10.1016/j.dental.2018.09.009.
2. Franz, A. et al., 2014. Cytotoxicity of post and core composites as a function of environmental conditions. Dental Materials, 30(10), pp.1179–1186. Available at: http://dx.doi.org/10.1016/j.dental.2014.07.011.
3. Dauti, R. et al., 2016. Comparison of marginal fit of cemented zirconia copings manufactured after digital impression with lava™ C.O.S and conventional impression technique. BMC Oral Health, 16(1). Available at: http://dx.doi.org/10.1186/s12903-016-0323-8.
4. Schmid-Schwap, M. et al., 2009. Cytotoxicity of four categories of dental cements. Dental Materials, 25(3), pp.360–368. Available at: http://dx.doi.org/10.1016/j.dental.2008.08.002.
5. Franz, A. et al., 2009. Cytotoxic effects of dental bonding substances as a function of degree of conversion. Dental Materials, 25(2), pp.232-239. Available at: http://dx.doi.org/10.1016/j.dental.2008.07.003.