Lymphoma, Non-Hodgkin; Sex-specific Differences
Lymphoid malignancies particularly of the B-cell type are among the most common malignancies in Western countries. They are also characterized by a male preponderance and a more benevolent disease course in women. We try to elucidate the bases of these sex-specific differences which not only seem to have an impact on the molecular characteristics of the malignant cells but also on clinical presentation and response to treatment.
- Vanura, K. (2021) ‘Sex as decisive variable in lymphoid neoplasms—an update’, ESMO Open, 6(1), p. 100001. Available at: http://dx.doi.org/10.1016/j.esmoop.2020.100001.
- Allain, E.P. et al. (2019) ‘Inactivation of Prostaglandin E2 as a Mechanism for UGT2B17-Mediated Adverse Effects in Chronic Lymphocytic Leukemia’, Frontiers in Oncology, 9. Available at: http://dx.doi.org/10.3389/fonc.2019.00606.
- Allain, E.P. et al. (2018) ‘Sex-dependent association of circulating sex steroids and pituitary hormones with treatment-free survival in chronic lymphocytic leukemia patients’, Annals of Hematology, 97(9), pp. 1649–1661. Available at: http://dx.doi.org/10.1007/s00277-018-3356-z.
- Freund, P. et al. (2016) ‘Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation’, PLOS ONE. Edited by G. Velasco, 11(6), p. e0156693. Available at: http://dx.doi.org/10.1371/journal.pone.0156693.
- Brunhofer-Bolzer, G. et al. (2015) ‘SAR-Guided Development and Characterization of a Potent Antitumor Compound toward B-Cell Neoplasms with No Detectable Cytotoxicity toward Healthy Cells’, Journal of Medicinal Chemistry, 58(3), pp. 1244–1253. Available at: http://dx.doi.org/10.1021/jm501848m.