- Weninger Lab
Research Area: The focus of the Weninger lab rests on studying biomedical model organisms and human body donors with traditional dissection, innovative experimental approaches and cutting edge imaging technologies.
My research focuses on imaging and phenotyping mouse embryos of embryonically lethal KO-lines. Using large numbers of data we define the normal morphology of mouse embryos that have completed organogenesis and use those reference data to identify KO-lines that can be used als model for rare diseases.
A second focus of my research is on peripheral nerves which is mainly conducted on human body donor material. Here we investigate macroscopic topological research questions emerging from clinical practice as well as the the intraneural topology using high-resolution imaging methods.
Techniques, methods & infrastructure
To image embryos, as well as other biological tissues, we use the High Resolution Epicscopic Microscopy (HREM) which generates 3D data in nearly histological resolution.
To answer various research questions we can make use of a well structured body donor facility, which is a powerful resource for maco- and microscopical investigations of the human body.
- Reissig, L.F. et al. (2022) ‘Detailed characterizations of cranial nerve anatomy in E14.5 mouse embryos/fetuses and their use as reference for diagnosing subtle, but potentially lethal malformations in mutants’, Frontiers in Cell and Developmental Biology, 10. Available at: http://dx.doi.org/10.3389/fcell.2022.1006620.
- Reissig, L.F. et al. (2022) ‘Spinal cord from body donors is suitable for multicolor immunofluorescence’, Histochemistry and Cell Biology [Preprint]. Available at: http://dx.doi.org/10.1007/s00418-022-02154-5.
- Reissig, L.F. et al. (2021) ‘Artefacts in Volume Data Generated with High Resolution Episcopic Microscopy (HREM)’, Biomedicines, 9(11), p. 1711. Available at: http://dx.doi.org/10.3390/biomedicines9111711.
- Reissig, L.F. et al. (2021) ‘Hypoglossal Nerve Abnormalities as Biomarkers for Central Nervous System Defects in Mouse Lines Producing Embryonically Lethal Offspring’, Frontiers in Neuroanatomy, 15. Available at: http://dx.doi.org/10.3389/fnana.2021.625716.
- Reissig, L.F. et al. (2022) ‘Effects and risks of performing a single incision endoscopic plantar fasciotomy — An anatomical study’, Foot and Ankle Surgery, 28(5), pp. 663–666. Available at: http://dx.doi.org/10.1016/j.fas.2021.08.004.