Detail

Keywords

Antibiosis; Bacterial Infections; Clinical Trial, Phase I; Dose-Response Relationship, Drug; Drug Approval; Drug Interactions; Drug Monitoring; Microdialysis; Pharmacokinetics

Research interests

Beside clinical trial design and regulatory science in general, my scientific interests cover antimicrobial agents with focus on pharmacokinetics, PK/PD and protein binding as well as cellular transporters and pharmacogenetics. By performing clinical studies in healthy volunteers and patients I aim at elucidating the impact of genetic variants and various pathophysiological states on pharmacokinetics and pharmacodynamics.

Another focus is drug-drug interactions as well as therapeutic drug monitoring (TDM).