Detail

Keywords

Alopecia Areata; Dermatitis, Atopic; Hidradenitis Suppurativa; Lymphoma, B-Cell; Lymphoma, T-Cell, Peripheral; Psoriasis

Research interests

Our research focuses on chronic inflammatory skin diseases such as atopic dermatitis, psoriasis and alopecia areata, but also malignancies derived from immune cells such as primary cutaneous T- and B-cell lymphomas. We want to better understand how individual immune cells orchestrate skin inflammation and host defense, including the crosstalk of infiltrating immune cells with skin-resident cells. With a strong focus on the human immune system, we ultimately want to identify relevant pathogenic players that could serve as therapeutic targets, to facilitate the development of novel treatment options for patients suffering from these chronic conditions.

Selected publications

1. Rojahn, T.B. et al., 2020. Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis. Journal of Allergy and Clinical Immunology. Available at: http://dx.doi.org/10.1016/j.jaci.2020.03.041.
2. Brunner, P.M. et al., 2019. Baseline IL-22 expression in patients with atopic dermatitis stratifies tissue responses to fezakinumab. Journal of Allergy and Clinical Immunology, 143(1), pp.142,
3. Brunner, P.M. et al., 2018. Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations. Journal of Allergy and Clinical Immunology, 141(6), pp.2094,
4. Stoffel, E. et al., 2018. Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics. British Journal of Dermatology, 178(5), pp.1151,
5. Brunner, P.M. et al., 2019. The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease. Journal of the American Academy of Dermatology, 81(2), pp.510,