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Shweta Tikoo
Dr. Shweta Tikoo, Ph.DPrincipal Investigator


Breast Cancer; Drug Discovery; Hematopoiesis; Hematopoietic System; High-Throughput Screening Assays; Imaging, Three-Dimensional; Inflammation; Innate Immunity; Macrophages; Melanoma; Melanoma, Amelanotic; Monocyte-Macrophage Precursor Cells; Myeloid Cells; Myeloid Progenitor Cells

Research interests

1. Deciphering the ontogeny of macrophage development in health and disease

2. Elucidating the role of perivascular macrophages in breast cancer development and metastasis

3. Imaging dynamics of immune cells in the melanoma tumour microenvironment

4. Understanding the role of perivascular macrophages in contact hypersensitivity

5. Targeting protein trafficking pathways in melanoma

6. Understanding the role of perivascular macrophages in leukocyte trafficking during sterile inflammation

Selected publications

  1. Tikoo S*, Jain R*,#, Martinez B, Rizzetto S, Shaw L, Mitchell AJ, Pacheco EMT, Luciani F, Jung S, Fraser ST, and Weninger W#. A yolk sac independent erythro-myeloid progenitor resides in the bone marrow and generates macrophages during inflammation in the adult. bioRxiv *Equal first authors, # Co-corresponding authors
  2. Tikoo S*, #,†, Jain R*, Tomasetig F, On K, Martinez B, Heu C, Stehle D, Obeidy, P, Guo D, Vincent JN, Cook AJL, Roediger B, Feil R, Whan RM, and Weninger W#. Amelanotic B16-F10 melanoma compatible with advanced 3D-imaging modalities. The Journal of Investigative Dermatology, 141(8): 2090-2094, *Equal first authors, #Co-senior authors, †Corresponding author
  3. Jain R*,#, Tikoo S*, On K, Martinez B, and Weninger W#. Visualising immune response in murine breast tumours by intravital multiphoton microscopy. STAR Protocols 2, 100722, *Equal first authors, #Co-corresponding authors
  4. Tikoo, S*, Barki, N*, Jain, R, et al. Imaging of Mast Cells. Immunological reviews, 282(1):58-72, *Equal first authors #Co-corresponding authors
  5. Tikoo S, Madhavan V, et al. Ubiquitin-dependent recruitment of the Bloom Syndrome helicase in response to replication stress is required to suppress homologous recombination. EMBO Journal, 32(12): 1778-92