Immune System; Microbiology; Oncology; Urinary Bladder
- Research Lab Urology
Head: Shahrokh F. Shariat
My research focuses on urologic oncology – especially on molecular mechanisms and markers to improve diagnostics and prognostics in upper tract and urothelial bladder cancer. Moreover, I am investigating tumor immunology, the urogenital microbiome and its impact on chronic inflammation, stone formation and tumorigenesis.
Techniques, methods & infrastructure
Our lab is well equipped to complete standard DNA, RNA and protein expression analysis. Moreover, we perform Next Generation Sequencing and drug screening on patient derived tumor cell lines.
- Lemberger, U.J. et al., 2018. Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice. Oncotarget, 9(13). Available at: http://dx.doi.org/10.18632/oncotarget.24346.
- Lemberger, U.J. et al., 2016. Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease. Oncotarget, 7(52). Available at: http://dx.doi.org/10.18632/oncotarget.13521.
- Kantari-Mimoun, C. et al., 2017. Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice. Oncotarget, 8(9). Available at: http://dx.doi.org/10.18632/oncotarget.14749.