Mag. Dr. Verena PichlerHead of Medical Radiochemistry and Biomarker Development; Head of Production PET-radiotracer
Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Research Associate (Postdoc)
ORCID: 0000-0003-4544-2438
T +43 1 40400 78300
verena.pichler@meduniwien.ac.at
Keywords
Diagnostic Imaging; Drug Discovery; Positron-Emission Tomography; Radiochemistry
Research interests
Drug development of imaging and therapeutic probes radiolabelled with carbon-11, fluorine-18, gallium-68, lutetium-177 and their preclinical and clinical evaluation.
Techniques, methods & infrastructure
- Drug development: synthetic inorganic and organic chemistry (schlenk technique), radiochemistry
- Analytical drug investigations: analytical and preparative HPLC (stability, lipophilicity, metabolism), 2D- and 3D- NMR, UV-Vis and IR spectroscopy
- In vitro techniques: preclinical 2D and 3D techniques (spheroid culture), antiproliferation assays, drug accumulation, FACS analysis, western blot, fluorescence microscopy
Selected publications
- Pichler, V. et al., 2015. Influence of reducing agents on the cytotoxic activity of platinum( iv ) complexes: induction of G 2 /M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines . Metallomics, 7(7), pp.1078-1090. Available at: http://dx.doi.org/10.1039/c5mt00116a.
- Pichler, V. et al., 2018. An Overview of PET Radiochemistry, Part 1: The Covalent Labels18F,11C, and13N. Journal of Nuclear Medicine, 59(9), pp.1350–1354. Available at: http://dx.doi.org/10.2967/jnumed.117.190793.
- Pichler, V. et al., 2013. Maleimide-functionalised platinum(iv) complexes as a synthetic platform for targeted drug delivery. Chemical Communications, 49(22), p.2249. Available at: http://dx.doi.org/10.1039/c3cc39258a.
- Pichler, V. et al., 2012. Unsymmetric Mono- and Dinuclear Platinum(IV) Complexes Featuring an Ethylene Glycol Moiety: Synthesis, Characterization, and Biological Activity. Journal of Medicinal Chemistry, 55(24), pp.11052-11061. Available at: http://dx.doi.org/10.1021/jm301645g.
- Pichler, V. et al., 2018. Molar activity – The keystone in 11C-radiochemistry: An explorative study using the gas phase method. Nuclear Medicine and Biology, 67, pp.21–26. Available at: http://dx.doi.org/10.1016/j.nucmedbio.2018.09.003.