Department of Pediatrics and Adolescent Medicine (Clinical Division of Neonatology, Intensive Care Medicine and Neuropediatrics)
Position: Professor
ORCID: 0000-0002-8113-3416
johannes.gojo@meduniwien.ac.at
Keywords
Brain tumor biomarkers; Neurooncology; Rare Diseases
Research group(s)
- Pediatric Neuro-Oncology
Research Area: - Precision oncology for pediatric CNS tumors - Development of innovative tumor models for pediatric CNS tumors - Identification of novel targets and therapies for pediatric CNS tumors - Discovery and translational application of biomarkers with focus on liquid biopsy
Members:
Research interests
My research is focused on delivering precision medicine approaches to children suffering from tumors of the central nervous system (CNS). A particular focus is the development of innovative tumor models for these rare diseases in order to allow detailed preclinical research. Therefore, my research interests range from deciphering the molecular mechanisms underlying the malignant phenotype of pediatric high-risk CNS tumors to develpment of novel biomarkers for disease montoring such as liquid biopsies.
Current ongoing projects are focused on various high-risk brain tumors including ependymoma, HGNET-BCOR, high-grade glioma and ETMR.
Techniques, methods & infrastructure
- precision oncology
- in vitro patient-derived cell models
- liquid biopsy (cerebrospinal fluid, blood)
Selected publications
- Mayr, L. et al. (2025) “Effective targeting of PDGFRA-altered high-grade glioma with avapritinib,” Cancer Cell. Edited by , 43(4), pp. 740–756.e8. Available at: https://doi.org/10.1016/j.ccell.2025.02.018.
- Gojo, J. et al., 2020. Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell, 38(1), pp.44,
- Laemmerer, A. et al. (2024) “Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens,” Neuro-Oncology. Edited by , 27(3), pp. 811–827. Available at: https://doi.org/10.1093/neuonc/noae228.
- Madlener, S. et al. (2025) “Detection of H3F3A K27M or BRAF V600E in liquid biopsies of brain tumor patients as diagnostic and monitoring biomarker: impact of tumor localization and sampling method,” Acta Neuropathologica. Edited by , 149(1). Available at: https://doi.org/10.1007/s00401-024-02842-7.
- Smith, K.S. et al. (2026) “M-PACT leverages cell-free DNA methylomes to achieve robust classification of pediatric brain tumors,” Nature Cancer. Edited by , 7(4), pp. 667–683. Available at: https://doi.org/10.1038/s43018-026-01115-4.