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Detail

Claudia Gundacker
Assoc. Prof. Priv. Doz. Mag. Dr. Claudia Gundacker

Center for Pathobiochemistry and Genetics (Institute of Medical Genetics )
Position: Associate Professor

ORCID: 0000-0003-4093-3780
T +43 1 56503
claudia.gundacker@meduniwien.ac.at

Further Information

Keywords

Environmental Health; Environmental Pollutants; Genetics, Medical; Placenta

Research group(s)

  • Environmental Health and Medical Ecology
    Head: Claudia Gundacker
    Research Area: Reproduction Toxicology and Environmental Health with specific emphasis on the metabolism and transport of metals (mercury, iron, lead, and cadmium) and perfluoroalkyl substances across the human placenta.
    Members:

Research interests

My research interest is in Reproduction Toxicology and Environmental Health with emphasis on metabolism and transport of metals (mercury, iron, lead, and cadmium) and per- and polyfluoralkyl substances (PFAS) across the human placenta. In search of proteins that mediate placental kinetics, i.e., uptake, distribution, biotransformation, and efflux of the substances, we combine Human Biomonitoring and genotyping with basic research on placental in vitro models. The aim is to identify genetic variants related to placental dysfunctions and pregnancy diseases.

 

Techniques, methods & infrastructure

Human Biomonitoring, Genotyping, Molecular biology, Cell culture, Placental primary cells, Trace element analysis (AFS, AAS)

Grants

Selected publications

  1. Gundacker, C. et al., 2021. Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility. International Journal of Hygiene and Environmental Health, 238, p.113855. Available at: http://dx.doi.org/10.1016/j.ijheh.2021.113855.
  2. Gundacker, C. et al., 2021. Gene Variants Determine Placental Transfer of Perfluoroalkyl Substances (PFAS), Mercury (Hg) and Lead (Pb), and Birth Outcome: Findings From the UmMuKi Bratislava-Vienna Study. Frontiers in Genetics, 12. Available at: http://dx.doi.org/10.3389/fgene.2021.664946.
  3. Gundacker, C. & Ellinger, I., 2020. The unique applicability of the human placenta to the Adverse Outcome Pathway (AOP) concept: the placenta provides fundamental insights into human organ functions at multiple levels of biological organization. Reproductive Toxicology, 96, pp.273–281. Available at: http://dx.doi.org/10.1016/j.reprotox.2020.07.014.
  4. Granitzer, S. et al., 2020. In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta. Archives of Toxicology, 94(11), pp.3799–3817. Available at: http://dx.doi.org/10.1007/s00204-020-02900-5.
  5. Widhalm, R. et al., 2020. Human placental cell line HTR-8/SVneo accumulates cadmium by divalent metal transporters DMT1 and ZIP14. Metallomics, 12(11), pp.1822–1833. Available at: http://dx.doi.org/10.1039/d0mt00199f.