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Martin Krssak
Mag. Dr. Martin KrssakAssociate Professor of Medical Physics

Department of Medicine III (Division of Endocrinology and Metabolism)
Position: Associate Professor

T +43 1 40400 37710
martin.krssak@meduniwien.ac.at

Keywords

Diabetes Mellitus, Experimental; Magnetic Resonance Spectroscopy; Physiology

Research interests

Non invasive assessment of ectopic lipid accumulation, glucose fluxes and ATP-handling in skeletal muscle, liver and myocardium by in vivo NMR spectroscopy.

Method development and integrative applications for the research of pathophysiology of diabetes mellitus and non-alcoholic fatty liver diseases as well as aging and sports physiology.

Techniques, methods & infrastructure

In vivo Magnetic Resonance Spectroscopy and Imaging: 13C, 31P, 1H, 2H spectroscopy – muscle, liver, heart, brain – focus on glucose, lipid and energy metabolism

Fat/Water MRI, Dynamic contrast enhanced MRI, parameter selective MRI, molecular imaging

Broad experience with different MR systems (clinical, whole body experimental, animal) and field strength (1.5, 3, 7 & 9.4 T)

Cooperation with Centre of Excellence - High Field MR (Prof. Trattnig, Prof. Bogner) and Preclinical Imaging Laboratory (Prof. Helbich), Department of Biomedical Imaging and Image guided Therapy (Radiodiagnostik und Nuklearmedizin).

Grants

Selected publications

  1. Krssak, M. et al. (1999) ‘Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study’, Diabetologia, 42(1), pp. 113–116. Available at: https://doi.org/10.1007/s001250051123.
  2. Krssak, M. et al. (2004) ‘Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes’, Diabetes, 53(12), pp. 3048–3056. Available at: https://doi.org/10.2337/diabetes.53.12.3048.
  3. Krššák, M. et al. (2020) ‘Proton magnetic resonance spectroscopy in skeletal muscle: Experts’ consensus recommendations’, NMR in Biomedicine, 34(5). Available at: https://doi.org/10.1002/nbm.4266.
  4. Ehret, V. et al. (2024) ‘Evaluation of Hepatic Glucose and Palmitic Acid Metabolism in Rodents on High‐Fat Diet Using Deuterium Metabolic Imaging’, Journal of Magnetic Resonance Imaging [Preprint]. Available at: https://doi.org/10.1002/jmri.29437.
  5. Klepochová, R. et al. (2024) ‘Correlation between skeletal muscle acetylcarnitine and phosphocreatine metabolism during submaximal exercise and recovery: interleaved 1H/31P MRS 7 T study’, Scientific Reports, 14(1). Available at: https://doi.org/10.1038/s41598-024-53221-x.