Department of Dermatology
Position: Associate Professor
ORCID: 0000-0003-2461-0367
T +43 1 40160 63001 or 40400 58330
adelheid.elbe-buerger@meduniwien.ac.at
Keywords
Allergy and Immunology; Fungi; Langerhans Cells; Models, Biological; Skin; T Cells
Research group(s)
- Cellular and Molecular Immunobiology of the Skin
Head: Adelheid Elbe-Bürger
Research Area: Investigations about the physiology of the human skin immune system and the origin, relationship and function of skin leukocytes in health and disease applying cutting edge technology.
Members:
Research interests
The research group "Cellular and Molecular Immunobiology of the Skin" is focussed on understanding the complex physiology of the human and mouse skin immune system, including precise investigations on the origin, relationship and function of skin leukocytes in health and disease. One central emphasis is on unravelling the intricacies of the prenatal human skin immune system as well as shedding light on its formation and functionality. In addition, the establishment of innovative primary human ex vivo skin models has driven applied research on the so far largely unknown effects of widely used active ingredients for wound care as well as on studies regarding the treatment or inhibition of infections with clinically highly relevant skin pathogens.
Techniques, methods & infrastructure
State-of-the-art methodologies in cellular and molecular biology as well as cutting-edge technologies such as single-cell RNA sequencing techniques and proteomics approaches.
Grants
- Skin barrier immune defence against the multidrug- resistant fungal pathogen Candida auris (2023)
Source of Funding: LEO Foundation, Stand-Alone Project
Principal Investigator - Development of adaptive human skin immunity (2018)
Source of Funding: FWF (Austrian Science Fund), Stand-Alone Project
Principal Investigator - Physiology of the skin immune system with a focus on origin, relationship and function of skin leukocytes in health and disease (2012)
Source of Funding: FWF (Austrian Science Fund), PhD Program, Molecular, Cellular and Clinical Allergology (MCCA)
Principal Investigator
Selected publications
- Cichoń, M.A. et al. (2022) ‘Interoperability of RTN1A in dendrite dynamics and immune functions in human Langerhans cells’, eLife, 11. Available at: http://dx.doi.org/10.7554/elife.80578.
- Reitermaier, R. et al. (2021) `αβγδ T cells play a vital role in fetal human skin development and immunity’, Journal of Experimental Medicine, 218(4). Available at: http://dx.doi.org/10.1084/jem.20201189.
- McGovern, N. et al., 2017. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature, 546(7660), pp.662-666. Available at: http://dx.doi.org/10.1038/nature22795.
- Tajpara, P. et al. (2019) ‘A Preclinical Model for Studying Herpes Simplex Virus Infection’, Journal of Investigative Dermatology, 139(3), pp. 673–682. Available at: http://dx.doi.org/10.1016/j.jid.2018.08.034.
- Schuster, C. et al., 2009. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. The Journal of Experimental Medicine, 206(1), pp.169-181. Available at: http://dx.doi.org/10.1084/jem.20081747.