Detail

Keywords

Skin

Research group(s)

• Cellular and Molecular Immunobiology of the Skin
  Head: Adelheid Elbe-Bürger
  Research Area: Investigations about the physiology of the human skin immune system and the origin, relationship and function of skin leukocytes in health and disease applying cutting edge technology.
  Members:
  Adelheid Elbe-Bürger

Research interests

Investigations about the physiology of the human skin immune system and the origin, relationship and function of skin leukocytes in health and disease.

Techniques, methods & infrastructure

State-of-the-art basic methodologies in cellular and molecular biology such as cell culture, functional and differentiation assay, ex vivo human skin (wound) models, ELISA, (immuno)histology, immunofluorescence, Western blot, cytokine array, FACS, CLSM, quantitative-RT-PCR.

Grants

• Development of adaptive human skin immunity (2018)
  Source of Funding: FWF (Austrian Science Fund), Stand-Alone Project
  Principal Investigator
• Deciphering T cell heterogeneity in prenatal human skin (2016)
  Source of Funding: OeNB (Oesterreichische Nationalbank), Anniversary Fund
  Principal Investigator
• Molecular, Cellular and Clinical Allergology (MCCA), Faculty Member (2012)
  Source of Funding: FWF (Austrian Science Fund), PhD Program
  Principal Investigator

Selected publications

1. Tajpara, P. et al., 2018. Epicutaneous administration of the pattern recognition receptor agonist polyinosinic-polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells. The FASEB Journal, 32(8), pp.4132-4144. Available at: http://dx.doi.org/10.1096/fj.201701090R.
2. Gschwandtner, M. et al., 2018. The Reticulum-Associated Protein RTN1A Specifically Identifies Human Dendritic Cells. Journal of Investigative Dermatology, 138(6), pp.1318-1327. Available at: http://dx.doi.org/10.1016/j.jid.2018.01.002.
3. McGovern, N. et al., 2017. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature, 546(7660), pp.662-666. Available at: http://dx.doi.org/10.1038/nature22795.
4. Vaculik, C. et al., 2012. Human Dermis Harbors Distinct Mesenchymal Stromal Cell Subsets. Journal of Investigative Dermatology, 132(3), pp.563-574. Available at: http://dx.doi.org/10.1038/jid.2011.355.
5. Schuster, C. et al., 2009. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. The Journal of Experimental Medicine, 206(1), pp.169-181. Available at: http://dx.doi.org/10.1084/jem.20081747.