Induced Pluripotent Stem Cells; Leg Ulcer; Mesenchymal Stem Cell Transplantation; Mesenchymal Stromal Cells; Pluripotent Stem Cells; Varicose Veins
- Disease Modeling and Organoid Technology Research Group
Research Area: development of in vitro and in vivo models of human diseases with a particular focus on vascular diseases affecting the skin
- Skin & Endothelium Research Division
Head: Peter Petzelbauer
Research Area: We characterize the phenotype and function of skin endothelium in the context of inflammation and cancer.
The “disease modeling and organoid technology” (DMOT) research group at the Department of Dermatology at the Medical University of Vienna focuses on the development of in vitro and in vivo models of human diseases with a particular focus on vascular diseases affecting the skin. Our lab combines clinical research with cutting-edge laboratory techniques with the ultimate goal of developing novel pharmaceutical approaches. This involves cellular reprogramming techniques, induced pluripotent stem cells, multipotent (adult) stem cells, in vitro (and in situ) tissue engineering approaches, pulsatile flow bioreactor systems, computational modeling as well as small animal in vivo models. The research group is embedded in the infrastructure of the “Skin and Endothelium Research Division” at the Anna-Spiegel Research building of the Medical University of Vienna, Austria.
- Generali M, Casanova EA, Kehl D, Wanner D, Hoerstrup SP, Cinelli P, Weber B. Autologous endothelialized small-caliber vascular grafts engineered from blood-derived induced pluripotent stem cells. Acta Biomater. 2019 Oct 1;97:333-343.
- Kehl D, Generali M, Mallone A, Heller M, Uldry AC, Cheng P, Gantenbein B, Hoerstrup SP, Weber B. Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential. Nature Partner Journal Regenerative Medicine (npj). 2019 Apr 16;4:8.
- Mallone A, Stenger C, Von Eckardstein A, Hoerstrup SP, Weber B. Biofabricating atherosclerotic plaques: In vitro engineering of a three-dimensional human fibroatheroma model. Biomaterials. 2018 Jan;150:49-59.
- Generali M, Kehl D, Capulli AK, Parker KK, Hoerstrup SP, Weber B. Comparative analysis of poly-glycolic acid-based hybrid polymer starter matrices for in vitro tissue engineering. Colloids Surf B Biointerfaces. 2017 Oct 1;158:203-212.
- Slamecka J, Salimova L, McClellan S, van Kelle M, Kehl D, Laurini J, Gross N, Cinelli P, Achermann J, Owen L, Hoerstrup SP, Weber B. Non-integrating episomal plasmid-based reprogramming of human amniotic fluid stem cells into induced pluripotent stem cells in chemically defined xeno-free conditions. Cell Cycle. 2015 Dec 10:0.