Detail

Keywords

Aging; Oxidative Stress; Phospholipids; Skin Aging

Research group(s)

• Christian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE
  Head: Florian Gruber
  Research Area: We investigate how environmental stress, pollution and time lead to accumulation of senescent cells in the skin and how these contribute to skin aging. Our focus lies on the SASP, the metabolism and the quality control of aging cells.
  Members:
  Florian Gruber
• Skin Biology - Florian Gruber
  Research Area: interaction of the skin with the environment; We investigate how the skin and its various cell types cope with intrinsic and extrinsic stressors and with aging; special focus: role of lipids and their oxidation
  Members:
  Florian Gruber

Research interests

My research is focussed on the role of bioactive lipid mediators in skin biology. We investigate the generation, the biochemistry and the signaling of lipid mediators in basic and translational research projects. 

Techniques, methods & infrastructure

Lipid Biology, Lipid analysis, Multimodal Imaging, Automated Tissue Analysis, Organotypic Skin Models

Selected publications

1. Narzt, M.-S. et al., 2019. A novel role for NUPR1 in the keratinocyte stress response to UV oxidized phospholipids. Redox Biology, 20, pp.467-482. Available at: http://dx.doi.org/10.1016/j.redox.2018.11.006.
2. Ni, C. et al., 2016. Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators. The International Journal of Biochemistry & Cell Biology, 81, pp.375-382. Available at: http://dx.doi.org/10.1016/j.biocel.2016.10.006.
3. Song, X. et al., 2017. Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo. Redox Biology, 11, pp.219-230. Available at: http://dx.doi.org/10.1016/j.redox.2016.12.015.
4. Narzt, M.-S. et al., 2021. Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors. Journal of Investigative Dermatology, 141(4), pp.993–1006.e15. Available at: http://dx.doi.org/10.1016/j.jid.2020.11.020.
5. Kremslehner, C. et al., 2020. Imaging of metabolic activity adaptations to UV stress, drugs and differentiation at cellular resolution in skin and skin equivalents – Implications for oxidative UV damage. Redox Biology, 37, p.101583. Available at: http://dx.doi.org/10.1016/j.redox.2020.101583.