Department of Laboratory Medicine
Position: Associate Professor
klaus.schmetterer@meduniwien.ac.at
Keywords
Adaptive Immunity
Research group(s)
- Schmetterer Lab
Research Area: T-cell regulation, immunopharmacology, tumor immunology
Members:
Research interests
The main research interest of the group is the understanding and manipulation of processes involved into the regulation of T-cell responses with focus on CD4+ effector and regulatory T-cells. One main area is the definiton of so far undefined transcription factors and signaling pathways which shape the phenotype and function of these cells. Furthermore, we use genome engineering tools to modulate signals in CD8+ effector T-cells in order to provide novel strategies for the improvement of adoptive immunotherapies in cancer.
Techniques, methods & infrastructure
Cell culture, Organoid cultures, Molecular biology methods (molecular cloning, real time PCR), Genome Engineering in primary human T-cells (CRISPR-knockout), ELISA, immunoblotting, multi-color flow cytometry (FACS), FACS-sorting
Grants
- The role of protein sulfation in CD8+ T cells (2025)
Source of Funding: FWF (Austrian Science Fund), stand alone grant
Principal Investigator - Assement of TRAT1 expression and function in CD4+ T-cells (2021)
Source of Funding: FWF (Austrian Science Fund), stand alone grant
Principal Investigator