Detail

Keywords

Chemokines; Clinical virology ; Serology

Research group(s)

• Comprehensive Serology and Chemokines in Clinical Virology
  Members:
  Lukas Weseslindtner

Research interests

Serology plays an essential role in the diagnosis of diverse viral diseases. The aim of my research is to evaluate the diagnostic abilities of comprehensive serological assays (avidity assays, epitope type specificity tests, immunoblots, microarrays, surrogate neutralization assays) in clinical virology and to investigate whether T-cell associated chemokines may serve as clinical markers to evaluate the stage, course and severity of different virus infections.

A specific aim of my current research is to assess and evaluate antibody assays in SARS-CoV-2, Parvovirus B19 and Measles virus infections.

Techniques, methods & infrastructure

• ELISAs and CLIAs
• Epitope-Type-Specifity (ETS) Assays
• IgG-avidity assays
• Immunoblots, Microarrays

Grants

• Diagnosis of SARS-CoV-2 infections and assessment of seroprevalence using antibody assays with the highest performance (2020)
  Source of Funding: Medical Scientific Fund of the Mayor of the City of Vienna, CoVID19 Research
  Principal Investigator

Selected publications

1. Springer, D.N. et al. (2025) ‘Seroprevalence against measles, Austria, stratified by birth years 1922 to 2024’, Eurosurveillance, 30(16). Available at: https://doi.org/10.2807/1560-7917.es.2025.30.16.2400684.
2. Springer, D.N. et al. (2024) ‘Measuring Variant-Specific Neutralizing Antibody Profiles after Bivalent SARS-CoV-2 Vaccinations Using a Multivariant Surrogate Virus Neutralization Microarray’, Vaccines, 12(1), p. 94. Available at: https://doi.org/10.3390/vaccines12010094.
3. Buchta, C. et al. (2023) ‘Three rounds of a national external quality assessment reveal a link between disharmonic anti-SARS-CoV-2 antibody quantifications and the infection stage’, Clinical Chemistry and Laboratory Medicine (CCLM), 61(7), pp. 1349–1358. Available at: https://doi.org/10.1515/cclm-2022-1161.
4. Springer, D.N. et al. (2022) ‘Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron Variant’, Microbiology Spectrum. Edited by M.G. Cusi, 10(5). Available at: https://doi.org/10.1128/spectrum.02129-22.
5. Semmler, G. et al. (2021) ‘Performance of Four IgM Antibody Assays in the Diagnosis of Measles Virus Primary Infection and Cases with a Serological Profile Indicating Reinfection’, Journal of Clinical Microbiology. Edited by Y.-W. Tang, 59(5). Available at: https://doi.org/10.1128/jcm.02047-20.