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Detail

Marius Ozenil
Ing. Dr. Marius Ozenil, MSc

Department of Biomedical Imaging and Image-guided Therapy (Division of Nuclear Medicine)
Position: Research Associate (Postdoc)

ORCID: 0000-0001-6369-6613
T +43 1 40400 78350
marius.ozenil@meduniwien.ac.at

Keywords

Drug Evaluation, Preclinical; Positron-Emission Tomography; Radiochemistry

Research interests

  • Radiochemical labeling of small molecules with cyclotron produced radionuclides (11C, 18F) including chemical synthesis of appropriate precursors
  • In vitro preclinical evaluation of potential PET tracers (e.g. parameters like ligand receptor kinetics, lipophilicity, plasma protein binding and metabolic stability

My PhD thesis focused on the development of PET tracers for neuroimaging of muscarinic acetylcholine receptors. Chemical derivatization of known mAChR ligands allowed to tune suitable pharmacological properties for tracer development.

Techniques, methods & infrastructure

Radiochemistry of PET nuclides (especially 11C, 18F), synthetic chemistry (organic and inorganic), analytical chemistry and structure identification (NMR, MS and other spectroscopic methods), chromatography (especially HPLC)

Selected publications

  1. Ozenil, M. et al., 2020. Enhanced arecoline derivatives as muscarinic acetylcholine receptor M1 ligands for potential application as PET radiotracers. European Journal of Medicinal Chemistry, 204, p.112623. Available at: http://dx.doi.org/10.1016/j.ejmech.2020.112623.
  2. Ozenil, M. et al., 2020. Synthesis, Biological, and Computational Evaluation of Antagonistic, Chiral Hydrobenzoin Esters of Arecaidine Targeting mAChR M1. Pharmaceuticals, 13(12), p.437. Available at: http://dx.doi.org/10.3390/ph13120437.