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Detail

Sam Augustine Kandathil
Sam Augustine Kandathil, M.D.

Center for Anatomy and Cell Biology (Division of Anatomy), Department of Otorhinolaryngology (Division of General Otorhinolaryngology)
Position: Doctor-in-training

ORCID: 0000-0003-4139-7940
T +43 1 40160-37758
sam.kandathil@meduniwien.ac.at

Keywords

Anatomic Variation; Anatomy; Autophagy; Chemoradiotherapy; Chemotherapy resistance; Free Tissue Flaps; Head and Neck Neoplasms; Mandibular Reconstruction; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microsurgery; Neck Dissection; Oncology; Organoids; Primary Cell Culture; Receptors, Interleukin-6; Reconstructive Surgical Procedures; Spheroids, Cellular; Translational Medical Research

Research group(s)

  • Basic Oncology Research in Head and Neck Cancer
    Members:
  • Bio-/Implantlab
    Head: Lena Hirtler
    Research Area: The members of this research group address a wide range of anatomical and clinical-morphological questions. By establishing the "Medical Bio-/Implantbank Vienna", it is possible to analyse the interaction between implants and surrounding tissue on a large scale. Apart from stand-alone projects, the research group is characterized by collaborations with a variety of different departments to tackle current and relevant issues in clinical practice.
    Members:

Research interests

  • Translational research
    • patient-derived head and neck sqamous cell carcinoma (HNSCC) culture (cultivating and engineering HNSCC-organoids and spheroids)
    • patient-derived xenografts (PDX)
    • organoid-derived grafts (ODX)
    • 4-NQO mouse model
  • Tumor microenvironment (TME)
    • influence of TME on cancer chemo- and radioresistance
  • Autophagy
    • role of autophagy in cancer development and response to chemo- and radiotherapy
  • Extracellular matrix (ECM)
    • creating scaffolds and hydrogels derived from animals and humans for in vitro applications
    • influence of ECM on HNSCC tumor progression and invasion
  • Thin section histology
    • currently establishing Methylmethacrylat-based histology to analyse implant-tissue-interactions