Detail

Keywords

Aortic Aneurysm, Abdominal; Biomarkers, Pharmacological; Carotid Artery Diseases; Randomized Controlled Trial

Research group(s)

• Arge Brostjan
  Research Area: Vascular Disease; interplay of endothelial cells, platelets and leukocytes in pro-inflammatory activation, coagulation and angiogenesis
  Members:
  Wolf Eilenberg
  Johannes Klopf
  Anna Sotir

Research interests

 W. Eilenberg is a dedicated vascular surgeon at the Department of Surgery, Division of Vascular Surgery and has conducted his PhD project on the role of neutrophils in carotid disease, with a special focus on inflammatory components. In the last years, he has extended his research to the role of neutrophils and NETs in abdominal aortic aneurysms (AAAs). In close collaboration with Prof. Brostjan, PhD head of the associated research lab, he has investigated NET components as a novel biomarker and therapeutic target in AAA. Thus, with his expertise in clinics and research, W. Eilenberg is focused on translational science regarding the abdominal aortic aneurysm. Furthermore, he extended his research area on randomized control trials in AAA, presently metformin as “old medication, novel indication” and submitted a Horizon 2020 grant application with 10 international collaborators.

Techniques, methods & infrastructure

Translational research and multi-center clincial trials:

Mouse models for AAA, analyzing novel biomarkers for Neutrophil extracellular traps, translational analyis of new biomarkers in AAA disease through biobanking, consortium leader of an international multi-centre study in 8 different countries;

Selected publications

1. Eilenberg, W. et al., 2016. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is Associated with Symptomatic Carotid Atherosclerosis and Drives Pro-inflammatory State In'
2. Eilenberg, W. et al., 2017. NGAL and MMP-9/NGAL as biomarkers of plaque vulnerability and targets of statins in patients with carotid atherosclerosis. Clinical Chemistry and Laboratory Medicine (CCLM), 56(1). Available at: http://dx.doi.org/10.1515/cclm-2017-0156.
3. Eilenberg, W. et al., 2017. Neutrophil gelatinase associated lipocalin (NGAL) is elevated in type 2 diabetics with carotid artery stenosis and reduced under metformin treatment. Cardiovascular Diabetology, 16(1). Available at: http://dx.doi.org/10.1186/s12933-017-0579-6.
4. Eilenberg, W. et al., 2019. Neutrophil Gelatinase Associated Lipocalin (NGAL) for Identification of Unstable Plaques in Patients with Asymptomatic Carotid Stenosis. European Journal of Vascular and Endovascular Surgery, 57(6), pp.768,
5. Györi, G.P. et al., 2019. Preoperative ultrasound improves patency and cost effectiveness in arteriovenous fistula surgery. Journal of Vascular Surgery, 69(2), pp.526,