Detail

Keywords

Medical Physics; Molecular Imaging; Positron-Emission Tomography

Research group(s)

• Preclinical Imaging Lab
  Members:
  Daniela Laimer-Gruber
  Lena Zachhuber
  Claudia Kuntner-Hannes
  Silvester Bartsch

Research interests

My main research currently focuses on quantitative preclinical imaging using microPET/CT and microPET/MRI mostly in oncology and neurology. Moreover, I am interested in standardization of preclinical imaging procedures and protocols and I also perform pharmacokinetic modeling of obtained PET data.

Techniques, methods & infrastructure

microPET; microPET/CT; microPET/MR

Grants

• Comprehensive STRategies to tacKIE malignant tumors: from nanomedicine and theranostics to precision medicine / STRIKE (2023)
  Source of Funding: EU, Horizon 2020
  Principal Investigator
• Development of a “Chelate to Release” Labeling Platform for Synthesis of high molar activity Radiopharmaceuticals (2021)
  Source of Funding: FFG (Austrian Research Promotion Agency), Bridge
  Principal Investigator
• Combination therapy in combating cholangiocarcinoma (2020)
  Source of Funding: NÖ Forschungs- und Bildungsges.m.b.H. (NFB), Life Science Call 2019
  Coordinator of the collaborative project
• HYPERDIAMOND (2016)
  Source of Funding: EU, PHC-11-2015
  Principal Investigator
• Tau Imaging in a Transgenic Animal Model (2015)
  Source of Funding: FFG (Austrian Research Promotion Agency), Bridge
  Coordinator of the collaborative project

Selected publications

1. Filip, T. et al. (2021) ‘Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling’, Alzheimer’s Research & Therapy, 13(1). Available at: http://dx.doi.org/10.1186/s13195-021-00916-2.
2. Kuntner-Hannes, C. and Haemisch, Y. (eds) (2019) ‘Image Fusion in Preclinical Applications’. Available at: http://dx.doi.org/10.1007/978-3-030-02973-9.
3. Osborne, D.R. et al. (2016) ‘Guidance for Efficient Small Animal Imaging Quality Control’, Molecular Imaging and Biology, 19(4), pp. 485–498. Available at: http://dx.doi.org/10.1007/s11307-016-1012-3.
4. Denk, C. et al. (2014) ‘Development of a18F-Labeled Tetrazine with Favorable Pharmacokinetics for Bioorthogonal PET Imaging’, Angewandte Chemie International Edition, 53(36), pp. 9655–9659. Available at: http://dx.doi.org/10.1002/anie.201404277.
5. Kuntner, C. and Stout, D. (2014) ‘Quantitative preclinical PET imaging: opportunities and challenges’, Frontiers in Physics, 2. Available at: http://dx.doi.org/10.3389/fphy.2014.00012.