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Nicolas Kozakowski
MD Nicolas Kozakowski

Department of Pathology
Position: Associate Professor

ORCID: 0000-0001-9180-620X

Keywords

Immunohistochemistry; Kidney Transplantation; Microscopy; Microscopy, Confocal; Microscopy, Electron; Nephrology; Pathology; Proteomics; Transcriptome

Research group(s)

Research interests

I focus on the pathology of renal allograft rejection and, in particular, the microvascular inflammation occurring during humoral rejection. Under the auspices of the Banff Foundation, I actively co-chair two working groups - i) peritubular capillaritis and ii) thrombotic microangiopathy. 

Further interests are the pathology of thrombotic microangiopathy, renal diseases associated with monoclonal gammopathies, amyloidosis and membranous nephropathy.

Techniques, methods & infrastructure

Our techniques extend from classical histology to immunomorphological methods in light and electron microscopy, multiplex analyses, various molecular biology techniques, gene expression profiling and spatially resolved genomics. We seek to add mass spectrometry analyses to these techniques.

Selected publications

  1. Roufosse, C. et al. (2023) ‘The Banff 2022 Kidney Meeting Work Plan: Data-driven Refinement of the Banff Classification for Renal Allografts’, American Journal of Transplantation [Preprint]. Available at: https://doi.org/10.1016/j.ajt.2023.10.031. Available at: http://dx.doi.org/.
  2. Afrouzian, M. et al. (2023) ‘Thrombotic Microangiopathy in the Renal Allograft: Results of the TMA Banff Working Group Consensus on Pathologic Diagnostic Criteria’, Transplant International, 36. Available at: https://doi.org/10.3389/ti.2023.11590. Available at: http://dx.doi.org/.
  3. Loupy, A. et al. (2020) ‘The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell– and antibody-mediated rejection’, American Journal of Transplantation, 20(9), pp. 2318–2331. Available at: https://doi.org/10.1111/ajt.15898. Available at: http://dx.doi.org/.
  4. Kozakowski, N. et al. (2018) ‘An integrative approach for the assessment of peritubular capillaritis extent and score in low-grade microvascular inflammation—associations with transplant glomerulopathy and graft loss’, Nephrology Dialysis Transplantation, 34(1), pp. 166–174. Available at: https://doi.org/10.1093/ndt/gfy192. Available at: http://dx.doi.org/.
  5. Kozakowski, N. et al. (2015) ‘The diffuse extent of peritubular capillaritis in renal allograft rejection is an independent risk factor for graft loss’, Kidney International, 88(2), pp. 332–340. Available at: https://doi.org/10.1038/ki.2015.64. Available at: http://dx.doi.org/.