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MPM2 Diseases of Proteostasis

Protein homeostasis or ‘proteostasis’ involves a network of cellular processes that maintain the health of the proteome, including protein biogenesis, folding, quality control, trafficking, and degradation. Many diseases are the result of the proteostasis network. This module will develop a deep and mechanistic understanding of protein synthesis, folding, protein quality control, trafficking and protein turnover, which will be illustrated in the context of precision medicine by paradigmatic diseases, their diagnosis, and their treatment.


Module Overview

In Module 2, we will cover the basics of how proteins fold, including the role of molecular chaperones. We will examine how, where, and when proteins are synthesized as well as their targeting to subcellular compartments. We will investigate the role of post-translational modifications (PTMs) in protein folding and targeting, including the role of ubiquitination in protein quality control. The molecular basis of protein degradation by the

ubiquitin-proteosome system and the removal as well as the recycling of damaged or surplus cellular components by autophagy will be taught at a molecular and mechanistic level.

In the context of human disease, we will develop an overview of paradigmatic protein folding diseases including (i) mutations that affect protein folding (ii) protein aggregation diseases and (iii) defects in the protein quality control machinery. Students will be familiarized with patient clinical presentation, histopathological features, diagnosis, treatment strategy, clinical outcome, and future perspectives alongside a deep and mechanistic understanding of the disease itself.

Novel approaches to visualize and quantify protein aggregation in vivo through molecular imaging for diagnosis and therapy monitoring will be presented. We will examine a spectrum of pre-clinical and clinical therapeutic approaches, including novel approaches for targeted protein degradation and RNA-based therapeutics to restore correct protein synthesis and folding.

Teaching faculty include basic research scientists from the Max Perutz Labs, the Medical University of Vienna, the Center for Molecular Medicine, and the Boehringer Ingelheim Institute for Molecular Pathology, as well as Clinicians from the Medical University of Vienna. 


Module coordinators

Elif Karagöz

Elif Karagöz is an Assistant Professor at the Max Perutz Labs (Medical University of Vienna). Her research programme is dedicated to understanding the protein quality control mechanisms in cells that are necessary for a healthy proteome. Elif previously studied protein chaperones in the lab of Stefan Rudiger and the unfolded protein response (UPR) in the lab of Peter Walter.

Website

Ellen Gelpi

Ellen Gelpi trained in clinical neurology in Barcelona, Spain before specializing in neuropathology in Vienna. She then returned to Barcelona where she led the Brain Bank for neurodegenerative disorders (Hospital Clinic-IDIBAPS) for 8 years. She is now back in Vienna, in the Division of Neuropathology and Neurochemistry of the Department of Neurology at the Medical University of Vienna. As a clinical neuropathologist, Ellen leads the neurodegeneration area and the national reference center for the surveillance of human prion diseases.

Website