Center for Medical Physics and Biomedical Engineering
Position: PHD Student
ORCID: 0009-0001-4360-9866
sarah.grosshagauer@meduniwien.ac.at
Keywords
Brain; Brain Mapping; Functional Magnetic Resonance; Functional Neuroimaging; Medical Physics
Research group(s)
- Functional Magnetic Resonance Imaging
Head: Christian Windischberger
Research Area: Mapping the functional organization of the human brain
Members: - MR Physics
Research Area: MR Physics research group is perusing basic methodological research in the area of the magnetic resonance (MR) imaging and spectroscopy.
Members: - Brain Stimulation
Head: Martin Tik
Research Area: Martin Tik and his team specialize in transcranial magnetic stimulation (TMS) combined with functional magnetic resonance imaging (fMRI) to explore and modulate brain function. Their research discovered neural circuits involved in affective disorders, particularly depression. They utilize innovative approaches that integrate chronometric TMS with brain imaging. Collaborating with leading international institutions (Stanford, Toronto, Hongkong) they advance personalized brain stimulation therapy.
Members: - Transcranial Magnetic Stimulation
Head: Martin Tik
Research Area: Transcranial magnetic stimulation (TMS) is a non-invasive method that uses magnetic pulses to induce activation in targeted brain regions. TMS has a vast parameter space, and optimizing these settings is crucial for effective treatment. Dr. Tik is a global pioneer in using neuroimaging, particularly functional MRI, and interleaved TMS-fMRI to refine TMS parameters. His work advances precision medicine by tailoring brain stimulation to individual patients, ensuring the most effective outcome.
Members:
Research interests
My main research interest is the application of functional magnetic resonance imaging to further understand and advance non-invasive brainstimulation techniques, mainly transcranial magnetic stimulation. More precisely, I explore direct effects of TMS using interleaved TMS-fMRI. My emphasis is on understanding different aspects which could influence variability in TMS effects and thus also treatment response. Furthermore, I use neuronavigation techniques as well as electric field modelling to optimize workflows and gain further insights on potentially highly influential factors for TMS success.
Selected publications
- Grosshagauer, S. et al. (2024) ‘Chronometric TMS-fMRI of personalized left dorsolateral prefrontal target reveals state-dependency of subgenual anterior cingulate cortex effects’, Molecular Psychiatry, 29(9), pp. 2678–2688. Available at: https://doi.org/10.1038/s41380-024-02535-3.
- Vasileiadi, M. et al. (2023) ‘Improved brain stimulation targeting by optimising image acquisition parameters’, NeuroImage, 276, p. 120175. Available at: https://doi.org/10.1016/j.neuroimage.2023.120175.
- Góra, J. et al. (2024) ‘The sensitivity of radiobiological models in carbon ion radiotherapy (CIRT) and its consequences on the clinical treatment plan: Differences between LEM and MKM models’, Journal of Applied Clinical Medical Physics, 25(7). Available at: https://doi.org/10.1002/acm2.14321.
- Grosshagauer, S. et al. (2022) ‘Organs at risk dose constraints in carbon ion radiotherapy at MedAustron: Translations between LEM and MKM RBE models and preliminary clinical results’, Radiotherapy and Oncology, 175, pp. 73–78. Available at: https://doi.org/10.1016/j.radonc.2022.08.008.