Detail

Keywords

Dose-Response Relationship, Radiation; Heavy Ions; Medical Physics; Quality Assurance, Health Care; Radiation Oncology; Risk Management

Research group(s)

• Medical Radiation Research
  Head: Dietmar Georg
  Research Area: The vision of our group is the optimization of the treatment outcome of radiation oncology, alone or in combination with established chemotherapy or novel targeted strategies of drug treatment, with conventional photon or innovative ion-beams.
  Members:
  Wolfgang Lechner
  Sylvia Gruber
  Stefan Ecker
  Elisabeth S. Gruber
  Petra Trnkova
  Nicole Nesvacil
  Andreas Renner
  Dietmar Georg
  Ana Beatriz Dias
  Gerd Heilemann
  Hermann Fuchs
  Lorenz Langgartner
  Barbara Knäusl
  Peter Kuess

Research interests

• Dose determination at the macroscopic and microscopic level
• Image guided precision radiotherapy with high energy photon beams
• MR guided radiation oncology
• Supervised decision making and workflow automation
• Proton, Carbon-ion and Helium-ion therapy
• Dose response effects at cellular and tissue level (pre-clinical and clinical)

Techniques, methods & infrastructure

• State-of-the-art photon beam linear accelerator with kV-based image guidance technology
• State-of-the-art treatment planning for photon, proton, Carbon ion and brachytherapy
• Comprehensive equipment for point dose, 2D and 3D dose measurements
• GATE/GEANT4 based Monte Carlo simulations
• Pre-clinical irradiator (kV beams) and pre-clinical imaging
• Scanned proton and Carbon ions beam with active energy variation (synchrotron)
• AI based on neural networks 

Grants

• Image guided particle therapy of uveal melanoma with a multiport beam arrangement (2019)
  Source of Funding: FFG (Austrian Research Promotion Agency), BRIDGE
  Principal Investigator
• Proton and carbon ion response studies for chondrosarcoma – going beyond current radiobiological standards with 3D models (2019)
  Source of Funding: FWF (Austrian Science Fund), Stand alone project
  Coordinator of the collaborative project
• Magnetic resonance imaging guided proton therapy (2018)
  Source of Funding: FWF (Austrian Science Fund), Programme Clinical Research (KLIF)
  Principal Investigator

Selected publications

1. Verhaegen, F. et al., 2018. ESTRO ACROP: Technology for precision small animal radiotherapy research: Optimal use and challenges. Radiotherapy and Oncology, 126(3), pp.471–478. Available at: http://dx.doi.org/10.1016/j.radonc.2017.11.016.
2. Daniel, M. et al., 2017. Impact of hybrid PET/MR technology on multiparametric imaging and treatment response assessment of cervix cancer. Radiotherapy and Oncology, 125(3), pp.420–425. Available at: http://dx.doi.org/10.1016/j.radonc.2017.10.036.
3. Fuchs, H. et al., 2017. Magnetic field effects on particle beams and their implications for dose calculation in MR-guided particle therapy. Medical Physics, 44(3), pp.1149–1156. Available at: http://dx.doi.org/10.1002/mp.12105.
4. Georg, D., Knöös, T. & McClean, B., 2011. Current status and future perspective of flattening filter free photon beams. Medical Physics, 38(3), pp.1280–1293. Available at: http://dx.doi.org/10.1118/1.3554643.
5. Georg, D. et al., 2008. Image-Guided Radiotherapy for Cervix Cancer: High-Tech External Beam Therapy Versus High-Tech Brachytherapy. International Journal of Radiation Oncology*Biology*Physics, 71(4), pp.1272–1278. Available at: http://dx.doi.org/10.1016/j.ijrobp.2008.03.032.