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Detail

Elisabeth S. Gruber
Elisabeth S. Gruber, MD PhDSpecialist for General and Visceral Surgery, Specialist for General Medicine

Department of General Surgery (Division of Visceral Surgery)
Position: Consultant

ORCID: 0000-0002-8646-1865
elisabeth.s.gruber@meduniwien.ac.at

Further Information

Keywords

Adaptive Immunity; Cachexia; Gastrointestinal Neoplasms; Inflammation; Metabolism; Oncogenes; Pancreatic Cancer; Physical and Rehabilitation Medicine; Physical Fitness; Radiation Effects; Sarcopenia; Translational Medical Research; Tumor Markers, Biological

Research group(s)

Research interests

Translational surgical oncology in gastrointestinal cancer 

1.  Impact of ingested micro- and nanoplastics on gastrointestinal carcinogenicity 

  • objective: to analyze the uptake and deposition of plastic particels in gastrointestinal tissue and its carcinogenic consequences
  • aim: raise awareness of "plastic food products" and imply a rethink of consurmerism culture

2. Exploration of the impact of physical fitness on the outcome in pancreatic cancer patients

  • objective: to understand the impact of physical exercise as well as dietary support on pancreatic cancer outcome
  • aim: delevopment of a prehabilitation concept for pancreatic cancer patients

3. Exploration of predictive biomarkers in gastrointestinal cancer

  • project 1
    • objective: to explore tumor-host interactions by analysis of the patient's inflammation, immune and metabolic profile
    • aim: development of novel therapeutic approaches and biomarkers
  • project 2
    • objective: to understand the impact of the oncogene AF1Q/MLLT11 and its downstream targets
    • aim: development of novel AF1Q/MLLT11-mediated therapeutic approaches and biomarkers

4. Stimulation of adaptive immunity by elaboration of the appopriate radiation dosage to improve tumor immune surveillance in (colo)rectal cancer

  • objective: to explore quantitive and qualitiative radiation-induced immunomodulation
  • aim: definition of a supportive radiation protocol to promote tumor shrinkage/clearance 

Techniques, methods & infrastructure

  • Blood and tissue samples (biobank)
  • In-vitro cell culture methods, organoid-derived grafts (ODX)
  • Molecular pathology methods (protein DNA and RNA analysis)
  • Digital pathology
  • Laboratory animal and translational pathology, transgenic mouse modelling, patient-derived grafts (PDX), CRISPR-Cas9, RNA knock-down strategies

Grants

  • AF1Q in gastrointestinal cancer (2018)
    Source of Funding: OeAW (Austrian Academy of Sciences), Dr. Anton Oelzelt-Newin'sche Stiftung
    Coordinator of the collaborative project

Selected publications

  1. Gruber, E.S. et al. (2022) ‘To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity’, Exposure and Health [Preprint]. Available at: http://dx.doi.org/10.1007/s12403-022-00470-8.
  2. Gruber, E.S. et al. (2020) ‘The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray’, Cancers, 12(3), p. 563. Available at: http://dx.doi.org/10.3390/cancers12030563.
  3. Gruber, E.S. et al. (2020) ‘The Prognostic Index Independently Predicts Survival in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Resection’, Annals of Surgical Oncology, 27(6), pp. 2017–2024. Available at: http://dx.doi.org/10.1245/s10434-019-08161-6.
  4. Gruber, E. et al. (2019) ‘The Oncogene AF1Q is Associated with WNT and STAT Signaling and Offers a Novel Independent Prognostic Marker in Patients with Resectable Esophageal Cancer’, Cells, 8(11), p. 1357. Available at: http://dx.doi.org/10.3390/cells8111357.
  5. Gruber, E.S. et al. (2019) ‘Sarcopenia and sarcopenic obesity are independent adverse prognostic factors in resectable pancreatic ductal adenocarcinoma’, PLOS ONE. Edited by F.X. Real, 14(5), p. e0215915. Available at: http://dx.doi.org/10.1371/journal.pone.0215915.